Thermal decomposition of reduced glutathione in solution for organ preservation

Fialaire, Anne; Postaire, E.; Prognon, P.; Pradier, F.; Pradeau, D.

doi:10.1016/0731-7085(92)80064-t

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…It seems logical to assume that the tripeptide glutathione undergoes degradation during the harsh thiol etching conditions, retaining only a cysteine-like functionality attached to the gold clusters. 22 A similar carboxylic CLO peak can be found in the C8 and C4 capped samples, although the intensity of the peak is much smaller in these cases. The carbonyl stretch vibration is not observed in the C16 or C12 capped samples.…”

mentioning

confidence: 58%

Ligand control in thiol stabilized Au38 clusters

et al. 2012

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mentioning

confidence: 58%

Ligand control in thiol stabilized Au38 clusters

et al. 2012

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“…The fact that the overall amount of sulfur containing groups (SH + disulfide) did not differ between these samples and the samples without any reductant, except for the SH groups in the unextruded material, could be an indicator for the decomposition of these two reductants during processing. The sulfur containing group might have left the product as gaseous hydrogen sulfide 30,31 …”

Section: Resultsmentioning

confidence: 99%

“…The sulfur containing group might have left the product as gaseous hydrogen sulfide. 30,31 Samples containing sodium metabisulfite behaved differently. Because the compound exhibits a disulfide bond, rather than a SH group, the significant increase in SH groups for the unextruded material containing sodium metabisulfite suggests its activity even before processing.…”

Section: Sulfhydryl Groups and Disulfide Bondsmentioning

confidence: 99%

Cysteine, sodium metabisulfite, and glutathione enhance crosslinking between proteins during high moisture meat analog extrusion processing and may improve the fibrousness of the products

Richter,

Watanabe,

Bernin

et al. 2024

J Sci Food Agric

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BACKGROUNDHigh moisture meat analog (HMMA) products processed using extrusion have become increasingly popular in the last few years. Because the formation of disulfide bonds is believed to play a critical role in the texturization mechanism, this study aimed to understand how chemical compounds capable of reducing disulfide bonds, specifically cysteine, sodium metabisulfite, and glutathione, affect the texture and the chemical interactions between the proteins.METHODWheat protein blended with cysteine, sodium metabisulfite, or glutathione at levels of 0, 0.5, 1.0, 2.5, 5.0, and 7.5 g kg−1 was extruded at three different temperatures (115, 140, and 165 °C) using a co‐rotating twin‐screw extruder. The feed rate (85 g min−1), the moisture content (600 g kg−1), and the screw speed (300 rpm) were kept constant. Unextruded and extruded material was subjected to sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, polymeric protein fractionation, and sulfhydryl group/disulfide bond analysis. Extruded samples were further analyzed for their hardness and their anisotropic index.RESULTSThe inclusion of reductants significantly affected the structure of the obtained extrudates. Although reducing agents had a relatively small impact on the total amount of disulfide bonds, their action significantly enhanced crosslinking between the proteins. At select conditions, samples with high fibrousness were specifically obtained when cysteine or sodium metabisulfite was included at levels of 5.0 g kg−1.DISCUSSIONIn the presence of reducing agents, it is believed that disulfide bonds are split earlier during the process without binding to them, giving the protein strands more time to unravel and align, leading to a better flow behavior and more fibrous products. © 2024 Society of Chemical Industry.

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“…The formation of CuS highly relies on the reaction between newly formed zerovalent atomic Cu and S. According to previous studies related to sulfur nanoparticles synthesis, the use of different sulfur-containing compounds as the precursor would generate the sulfur nanoparticles with distinctive sizes and shapes, which would be attributed to the intrinsically different reaction mechanism in releasing zerovalent sulfur. For example, inorganic sulfuric ions (i.e., S 2 O 3 2– ) undergo a disproportionation reaction to form sulfur and sulfonic acid, while organic sulfuric compounds (i.e., GSH) tends to thermally decompose and release H 2 S at an elevated temperature, where H 2 S can further be reduced to generate zerovalent sulfur atoms. These different reaction pathways would cause the concentration of zerovalent sulfur atoms/nuclei formed in the initial stage to vary when the sulfur precursor was replaced, and thus, affect the nucleation and growth of CuS nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

“…) undergo a disproportionation reaction to form sulfur and sulfonic acid, 50 while organic sulfuric compounds (i.e., GSH) tends to thermally decompose and release H 2 S at an elevated temperature, 51 where H 2 S can further be reduced to generate zerovalent sulfur atoms. These different reaction pathways would cause the concentration of zerovalent sulfur atoms/ nuclei formed in the initial stage to vary when the sulfur precursor was replaced, and thus, affect the nucleation and growth of CuS nanoparticles.…”

Section: Effect Of Reaction Parameters On Product Morphologymentioning

confidence: 99%

Fatty Amine-Mediated Synthesis of Hierarchical Copper Sulfide Nanoflowers for Efficient NIR-II Photothermal Conversion and Antibacterial Performance

Jiao,

Wu,

Wang

et al. 2023

Langmuir

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Non-noble metal photothermal materials have recently attracted increasing attention as unique alternatives to noble metal-based ones due to advantages like earth abundance, cost-effectiveness, and large-scale application capability. In this study, hierarchical copper sulfide (CuS) nanostructures with tunable flower-like morphologies and dimensional sizes are prepared via a fatty amine-mediated one-pot polyol synthesis. In particular, the addition of fatty amines induces a significant decrease in the overall particle size and lamellar thickness, and their morphologies and sizes could be tuned using different types of fatty amines. The dense stacking of nanosheets with limited sizes in the form of such a unique hierarchical architecture facilitates the interactions of the electromagnetic fields between adjacent nanoplates and enables the creation of abundant hot-spot regions, thus, benefiting the enhanced second near-infrared (NIR-II) light absorptions. The optimized CuS nanoflowers exhibit a photothermal conversion efficiency of 37.6%, realizing a temperature increase of nearly 50 °C within 10 min under 1064 nm laser irradiations at a power density of 1 W cm–2. They also exhibit broad-spectrum antibacterial activity, rendering them promising candidates for combating a spectrum of bacterial infections. The present study offers a feasible strategy to generate nanosheet-based hierarchical CuS nanostructures and validates their promising use in photothermal conversion, which could find important use in NIR-II photothermal therapy.

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Thermal decomposition of reduced glutathione in solution for organ preservation

Cited by 4 publications

References 2 publications

Ligand control in thiol stabilized Au38 clusters

Ligand control in thiol stabilized Au38 clusters

Cysteine, sodium metabisulfite, and glutathione enhance crosslinking between proteins during high moisture meat analog extrusion processing and may improve the fibrousness of the products

Fatty Amine-Mediated Synthesis of Hierarchical Copper Sulfide Nanoflowers for Efficient NIR-II Photothermal Conversion and Antibacterial Performance

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