Thermal decomposition mechanism of piroxicam

Wu, C. H.; You, Jingsong; Wang, Xue Jie

doi:10.1007/s10973-018-7308-6

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Thermal analysis is routinely used in pharmaceutical research and development for understanding thermal behaviour of drugs that allows for prediction of thermal stability, purity and various physicochemical properties of pharmaceuticals ( Wu et al, 2018 ). Herein, we employed simultaneous TG-DSC analysis in order to evaluate thermal behaviour of pure lornoxicam and lornoxicam-laden microsponges and the results are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

He¹,

Majid

Maqbool

et al. 2020

Saudi Pharmaceutical Journal

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Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The microsponges were formulated using quasi emulsion-solvent diffusion method employing four different surfactant systems, namely polyvinyl alcohol (PVA), Tween80, Gelucire 48/16 and Gelucire 50/13. All the lornoxicam loaded microsponge formulations were extensively characterized with a variety of analytical tools. The optimized microsponge formulation was then converted into gel formulation. The lornoxicam loaded microsponge gel formulation had adequate viscosity and sufficient pharmaceutical properties as confirmed by the texture analysis and the drug release followed Super case II transport. It is noteworthy that we described the preparation of a new cellulosic polymers based microsponge system for delivery of lornoxicam to provide quick as well as lasting (sustained) anti-inflammatory effects in rats using carrageenan induced rat paw edema model. We were able to demonstrate a 72% reduction in inflammation within 4 h using the optimize transdermal gel formulation utilizing Transcutol P as permeation enhancer and with the aid of skin micro-piercing by microneedles, hence, demonstrating the potential of this microsponge gel formulation in arthritis management.

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Section: Resultsmentioning

confidence: 99%

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

He¹,

Majid

Maqbool

et al. 2020

Saudi Pharmaceutical Journal

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“…Similar predictions would have thusly been expected from an unmixed sample. On the other hand, PXCM and PHY were processed well below their melting points, and determining the API loading using these more traditional approaches would be challenging because PXCM degrades at its melting point [ 67 ] and the PHY melt is significantly higher than the PVP-VA64 degradation.…”

Section: Discussionmentioning

confidence: 99%

Material-Sparing Feasibility Screening for Hot Melt Extrusion

Pluntze,

Beecher,

Anderson

et al. 2024

Pharmaceutics

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Hot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at determining the thermodynamic solubility and do not take into account kinetics of dissolution or the associated degradation of the API during thermal processing, both of which are critical considerations in generating a successful amorphous solid dispersion by HME. This work aims to develop a material-sparing approach for screening manufacturability of a given pharmaceutical API by HME using physically relevant time, temperature, and shear. Piroxicam, ritonavir, and phenytoin were used as model APIs with PVP VA64 as the dispersion polymer. We present a screening flowchart, aided by a simple custom device, that allows rapid formulation screening to predict both achievable API loadings and expected degradation from an HME process. This method has good correlation to processing with a micro compounder, a common HME screening industry standard, but only requires 200 mg of API or less.

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“…If this is indeed the crystallization product, residual PRX must therefore recrystallize as a pure form and its melting may correspond to the endotherm observed at 180 C; this melting temperature is lower than that of known PRX, i.e. 207 C (Kerč et al, 1989;Barzegar-Jalali et al, 2014) under an ambient atmosphere and 195 C under an N 2 atmosphere (Wu et al, 2018). Depression of melting temperature is known to occur in multiphase mixtures (Umbreit et al, 2003;Rezende et al, 2008), and can be suggested to result from PRX interactions with the melted PRX-SA cocrystal.…”

Section: Figurementioning

confidence: 99%

An acetonitrile-solvated cocrystal of piroxicam and succinic acid with co-existing zwitterionic and non-ionized piroxicam molecules

et al. 2019

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This work reports a new acetonitrile (ACN)-solvated cocrystal of piroxicam (PRX) and succinic acid (SA), 2C 15 H 13 N 3 O 4 SÁ0.5C 4 H 6 O 4 ÁC 2 H 3 N or PRX:SA:ACN (4:1:2), which adopts the triclinic space group P1. The outcome of crystallization from ACN solution can be controlled by varying only the PRX:SA ratio, with a higher PRX:SA ratio in solution unexpectedly favouring a lower stoichiometric ratio in the solid product. In the new solvate, zwitterionic (Z) and non-ionized (NI) PRX molecules co-exist in the asymmetric unit. In contrast, the nonsolvated PRX-SA cocrystal contains only NI-type PRX molecules. The ACN molecule entrapped in PRX-SAÁACN does not form any hydrogen bonds with the surrounding molecules. In the solvated cocrystal, Z-type molecules form dimers linked by intermolecular N-HÁ Á ÁO hydrogen bonds, whereas every pair of NI-type molecules is linked to SA via N-HÁ Á ÁO and O-HÁ Á ÁN hydrogen bonds. Thermogravimetry and differential scanning calorimetry suggest that thermal desolvation of the solvate sample occurs at 148 C, and is followed by recrystallization, presumably of a multicomponent PRX-SA structure. Vibrational spectra (IR and Raman spectroscopy) of PRX-SAÁACN and PRX-SA are also used to demonstrate the ability of spectroscopic techniques to distinguish between NI-and Z-type PRX molecules in the solid state. Hence, vibrational spectroscopy can be used to distinguish the PRX-SA cocrystal and its ACN solvate.

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Thermal decomposition mechanism of piroxicam

Cited by 9 publications

References 24 publications

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

Material-Sparing Feasibility Screening for Hot Melt Extrusion

An acetonitrile-solvated cocrystal of piroxicam and succinic acid with co-existing zwitterionic and non-ionized piroxicam molecules

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