Thermal damage of tissue during near-infrared laser irradiation with assistance of light-absorbing dye

Abstract

The selective photothermal-tissue interaction using dye enhancement has been proven to be effective in minimizing the peripheral normal tissue damage during cancer treatment. It is important that the tissuethermal damage be analyzed and the damage rate process be estimated before the photothermalimmunotherapy for cancer treatment. In this study, we have used the EMT6 mouse tumor model for the laser-tumor treatment with a simultaneous surface temperature measurement using infrared thermography. The images acquired were processed to obtain the temperature profiles. The saturation temperature and corresponding time of irradiation from the temporal profiles were used to calculate the damage parameter using Arrhenius rate process equation. The damage parameters obtained from six mice were compared. Our results of in vivo study show that the damage analyses agree with the previous in vitro study on skins.