Thermal control of drug release by a responsive ion track membrane observed by radio tracer flow dialysis

Spohr, R.; Reber, N.; Wolf, A.; Alder, G. M.; Ang, V.; Bashford, C. L.; Pasternak, C. A.; Omichi, Hideki; Yoshida, Minoru

doi:10.1016/s0168-3659(97)00076-x

Cited by 55 publications

(31 citation statements)

References 32 publications

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“…A majority of previous studies involving thermoresponsive permeability control has exploited the LCST behavior of PNIPAAM [7,8,9,10,11]. For example, Akerman et al .…”

Section: Polymer Brushes and Their Responsive Mechanismsmentioning

confidence: 99%

“…These smart nanopores have been prepared by functionalizing the pores with a suitable responsive polymer that creates a switchable membrane permeability in response to variation in temperature [7,8,9,10,11], pH [12,13,14,15,16], ionic/solute concentration [12,17], and light [18,19]. Similarly, polymers that respond to electric fields [20,21] offer an additional triggering mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Stimuli-Responsive Polymer Brushes for Flow Control through Nanopores

Adiga

Brenner

2012

JFB

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Responsive polymers attached to the inside of nano/micro-pores have attracted great interest owing to the prospect of designing flow-control devices and signal responsive delivery systems. An intriguing possibility involves functionalizing nanoporous materials with smart polymers to modulate biomolecular transport in response to pH, temperature, ionic concentration, light or electric field. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions. In this work, an overview of nanoporous materials functionalized with responsive polymers is given. Various examples of pH, temperature and solvent responsive polymers are discussed. A theoretical treatment that accounts for polymer conformational change in response to a stimulus and the associated flow-control effect is presented.

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“…A majority of previous studies involving thermoresponsive permeability control has exploited the LCST behavior of PNIPAAM [7,8,9,10,11]. For example, Akerman et al .…”

Section: Polymer Brushes and Their Responsive Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Polymer Brushes for Flow Control through Nanopores

Adiga

Brenner

2012

JFB

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“…The methods of modifying polymeric surfaces, such as plasma and radiation treatments and graft polymerization, are very important for improving surface functionalities that are expected to play key roles in high-performance materials for artificial organs, [1] separation membranes, [2][3][4] and nanoscopic electronic devices. The treatment of polymer surfaces with corona, [5] plasma, [6,7] and radiation [8] treatments can modify surface hydrophilicity and adhesion to some extent; however, these methods are not suitable for the precise control of surface properties, i.e., the transformation of the chemical structure on the surface at a molecular level.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of a Poly(ethylene terephthalate) Surface by the Selective Alkylation of Acid Salts

Li¹,

Maekawa²,

Yamaki³

et al. 2002

Macro Chemistry & Physics

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Chemical modification of the hydrophilic surface of poly(ethylene terephthalate) (PET) was examined by the selective alkylation of the acid salt on the surface using acyl bromides as an electrophile with catalytic potassium fluoride. The hydrophobicity of the PET surface increased as the alkylation reaction of the hydrolyzed surface proceeded. The chemical incorporation of the alkylation reagents was confirmed by the presence of fluorine peaks in X‐ray photoelectron spectroscopy (XPS) from the fluorinated reagents. Exponential increases were observed in the emission and excitation intensities of fluorescence spectra during the reaction of the surface with a fluorescent reagent. This indicated that the esterification of carboxylic acids on the surface proceeded without deterioration of the reaction even at the later stages. The relation between changes in contact angles and the fluorescence spectra revealed that the hydrophobicity of a surface was quickly restored at the beginning of a reaction. magnified image

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“…However, although thermo-responsible gels have found applications for instance in chromatography, their application in the membrane manufacture came much later, since as a film they are not selfsupportable. Different approaches have been used to overcome this disadvantage, mainly the copolymerization and preparation of phase inversion porous membranes [124,125] and the manufacture of composite membranes by grafting onto high-strength polymeric micro-porous films such as track-etched polycarbonate [119] or PET membrane [126].…”

Section: Response To Temperaturementioning

confidence: 99%