Low efficiency heat exchangers used in automotive as radiator may cause to serious dangers for the engine. Hence, thermal scientists and engineers always pursuit modern methods to enhance the heat removal of the engine. It seems nanofluids implementation in automotive cooling system promises to achieve high efficiency radiators. This paper reviews almost all performed studies in this area that are available in the literature. Author collects details about nanoparticles materials and size, base fluid, volume, concentration, flow regime and Reynolds number used in studies. Usually, maximum heat transfer enhancement and maximum need to pumping power occurs at the highest volume concentration of nanoparticles, simultaneously. On the other hand, using nanofluids, due to the enhanced heat carrying capacity of the nanofluids; the pumping power required will also be reduced.