Thermal characterization of Plasmodium falciparum species specific proteins in Indian geographical area.

Abstract

The paper reveals thermal characteristics of P.falciparum species specific proteins. These proteins determine why P. vivex species are dominant over P.falciparum in Indian geographical area. Outside human host plasmodium parasite survives in poikilothermal mosquitoes. Climatic temperature conditions greatly affect native state of P.falciparum species specific proteins in mosquitoes. Study of climatic temperature conditions in Indian geographical area reveals that P fsd protein for Plasmodium falciparum can remain in native state between ≥7 0 c and ≤42.6 0 c temperature conditions. While their best optimum functions (activity) was noted between 25.3 0 c to 33 0 c. P fsd protein were found more heat susceptible for temperature minima and maxima than P vsd proteins of P. vivex causing all time high population ratio of P.falciparum species. Body