Thermal behaviour studies of procaine and benzocaine

Fuliaş, Adriana; Vlase, Gabriela; Grigorie, Carmen; Ledeți, Ionuț; Albu, Paul; Bilanin, Mihai

doi:10.1007/s10973-013-2959-9

Cited by 49 publications

(13 citation statements)

References 21 publications

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“…Synthesized compounds were evaluated for their antimicrobial activity and all the compounds showed significant activity [11]. Non-isothermal kinetics of chitosan [12], chitin [13], cephalosporins [14], procaine and benzocaine [15] and theobromine [16] were studied in details and appropriate the decomposition kinetics models were proposed.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Thermal Decomposition of a Spirooxindole Compound under Non-Isothermal Condition

2016

Can Chem Trans

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A spirooxindole compound, namely 2′-amino-6′-(1H-indol-3-yl)-2-oxospiro[indole-3,4′-pyran]-3′, 5′-dicarbonitrile (AIOIPD) has been synthesized and characterized by microanalysis, FT-IR, mass spectrum and NMR ( 1 H and 13 C) techniques. The thermal decomposition of the compound was studied by thermogravimetric analysis under dynamic nitrogen atmosphere at different heating rates of 10, 15, 20 and 30 K min -1 . The kinetic parameters were calculated using model fitting (Coats-Redfern, CR) and model-free methods (Friedman, Kissinger-Akahira-Sunose, KAS and Flynn-Wall-Ozawa, FWO). The decomposition process of AIOIPD followed a single step mechanism as evidenced from the data. Existence of compensation effect is noticed for the decomposition of AIOIPD. Invariant kinetic parameters are consistent with the average values obtained by Friedman and KAS inconversional methods.

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Section: Introductionmentioning

confidence: 99%

Kinetics of Thermal Decomposition of a Spirooxindole Compound under Non-Isothermal Condition

2016

Can Chem Trans

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“…The unique structural features of spirooxindoles together with diverse biological activities have made them privileged structures in new drug discovery [10]. Non-isothermal decomposition kinetics of chitosan [11], chitin [12], cephalosporins [13], procaine and benzocaine [14], theobromine [15] and spirooxindole [16] were studied in detail and appropriate kinetic models were proposed. 3-Chloro oxindoles are versatile starting materials for asymmetric organo catalytic synthesis of spirooxindoles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and thermal decomposition of 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro-[indoline-3,4’-pyran]-3’,5’-dicarbonitrile under non-isothermal condition in nitrogen atmosphere

Nalini¹,

Jayachandramani²,

Suresh

et al. 2016

Eur. J. Chem.

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“…It is combined with other techniques, such as FTIR, NMR, and XRD [17][18][19][20][21][22][23]. The main concept of this work is to determine the thermal properties of three derivatives of 3,4-pyridinedicarboximides (slightly differ in molecular structure).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and DSC study a new pyridinedicarboximide diones derivatives, obtained under various conditions

Krzy

2014

J Therm Anal Calorim

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The series of three 4-alkoxy-2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl]-6-methyl-1H-pyrrolo [3,4-c] pyridine-1,3(2H)-diones were synthesized. The structures of all formed compounds were identified by elemental analysis, FTIR, and 1 H NMR. The synthesized compounds were studied using differential scanning calorimetry and thermogravimetric analysis in order to determine the existence of multiple solid-state forms. Our measurements showed that the solvent, mechanical treatment, and quenching are the important factors. Two stable and one metastable modification were detected. Additionally, DFT calculations were performed.

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Thermal behaviour studies of procaine and benzocaine

Cited by 49 publications

References 21 publications

Kinetics of Thermal Decomposition of a Spirooxindole Compound under Non-Isothermal Condition

Kinetics of Thermal Decomposition of a Spirooxindole Compound under Non-Isothermal Condition

Synthesis, characterization and thermal decomposition of 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro-[indoline-3,4’-pyran]-3’,5’-dicarbonitrile under non-isothermal condition in nitrogen atmosphere

Synthesis and DSC study a new pyridinedicarboximide diones derivatives, obtained under various conditions

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