Thermal behaviour of some novel antimicrobials based on complexes with a Schiff base bearing 1,2,4-triazole pharmacophore

Badea, Mihaela; Calu, Larisa; Chifiriuc, Mariana Carmen; Bleoţu, Coralia; Marin, Alexandra; Ion, Sebastian; Ioniţă, Gabriela; Stănică, Nicolae; Măruţescu, Luminiţa; Lazăr, Veronica; Marinescu, Dana; Olar, Rodica

doi:10.1007/s10973-014-3821-4

Cited by 25 publications

(21 citation statements)

References 49 publications

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“…The structure of synthesized compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) was confirmed by the complex using of elemental analysis ( Table 2) and IR-spectrophotometry ( Table 3). The elemental composition of the compounds corresponds within the limits of the calculated data error ( Table 2).…”

Section: Resultsmentioning

confidence: 83%

“…There are absorption bands -C=N groups at 1610-1573 cm -1 , -OH groups at 3530-3488 cm -1 , -C-S groups at 707-620 cm -1 , and also absorption of aromatic ring bands at 1501-1470 cm -1 in the IR-spectra of all synthesized compounds. IR-spectra of acids (3,4) additionally contain absorption bands of -CH 2 -COOH groups at 1710-1700 cm -1 , and spectra of salts (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) contain bands that are inherent to COO-groups in the range of 1407-1300 cm -1 and at 1595-1536 cm -1 , respectively [13].…”

Section: Resultsmentioning

confidence: 99%

“…In planning the experiment, a generalization was made regarding the dependence of toxicity and pharmacological activity of substances, which have been synthesized recently on their structure [8,9]. Relying on the experience of previous studies [10] with the aim of creating new original drugs, the goal was to synthesize a series of 2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids on the basis of which salt is obtained, which, according to literature [11], has high pharmacological activity.…”

Section: Materials and Methods Of Researchmentioning

confidence: 99%

“…Ammonium 2-((5-(hydroxy(phenyl)methyl)-4-phenyl-4H-1,2,4-triazole-3-yl)thio) acetate (8,Table 1). 0.01 mole of 2-((5-(hydroxy(phenyl)methyl)-4-phenyl-4H-1,2,4-triazole-3-yl)thio)acetic acid (4) was dissolved in 30 ml of 25 % Ammonia and evaporated.…”

Section: Iron (Ii) Copper (Ii) and Zinc (Ii) 2-((5-(hydroxy(phenyl) mentioning

confidence: 99%

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Synthesis, physical and chemical properties of 2-((5-(hydroxy(phenyl)methyl)-4R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts

Rud

Kaplaushenko

Yurchenko

2018

ZMJ

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Today's a creation of new domestic medicines is very important problem for pharmacy and medicine. Therefore, it is relevant to synthesize new domestic biologically active compounds. It is known that a large number of new 3-thio and 4-amino derivatives on the basis of 1,2,4-triazole have recently been synthesized, among which compounds with high pharmacological activity have been found. Based on the experience of previous studies and with the aim of creating new original drugs, our goal was to synthesize 2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids series and to obtain salts on its basis, which have high indicators of pharmacological activity based on the literature data.The goal of the work is a targeted synthesis of potential low-toxic and highly effective compounds with a wide spectrum of pharmacological activity among 5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-thione derivatives, confirmation of their individuality and structure, as well as the study of physical-chemical properties, for the further pharmacological screening. Materials and methods.2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids were prepared by heating 5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazol-3-thiones with chloroacetic acid. Subsequently, the synthesized thioacetic acids were subject for modification. Salts of 2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids were obtained by reacting thioacetic acids with equivalents of sodium or potassium hydroxides.To obtain Iron (II), Copper (II) or Zinc (II) salts, half-molar amounts of the appropriate sulfates were added to the obtained solutions. Salts of 2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids with organic bases were obtained by the reaction of acids with piperidine or morpholine in ethanol medium. Results.During the synthetic studies, 13 previously undescribed new compounds were obtained. The individuality of 2-((5-(hydroxy(phenyl)methyl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts after recrystallization was confirmed by thin layer chromatography. The structure of synthesized compounds was confirmed by the integrated use of elemental analysis and IR-spectrophotometry. Conclusions.The results of the work confirm the structure of the synthesized compounds, which shows the possibility of further biological investigation.Синтез і фізико-хімічні властивості 2-((5-(гідрокси(феніл)метил)-4-R-4H-1,2,4-тріазол-3-іл)тіо)ацетатних кислот та їхніх солейСьогодні в галузі фармації та медицини гостро стоїть питання про створення нових ліків вітчизняного виробництва, які замінили б дорогі закордонні аналоги. Тому актуальним є синтез нових вітчизняних біологічно-активних сполук. Відомо, що на основі 1,2,4-тріазолу останнім часом синтезовано велику кількість нових 3-тіо та 4-амінопохідних, серед них знайдені сполуки, що мають високі показники фармакологічної активності. Спираючись на досвід попередніх досліджень щодо створення нових оригінальних лікарських препаратів, постав...

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Materials and Methods Of Researchmentioning

confidence: 99%

Section: Iron (Ii) Copper (Ii) and Zinc (Ii) 2-((5-(hydroxy(phenyl) mentioning

confidence: 99%

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Synthesis, physical and chemical properties of 2-((5-(hydroxy(phenyl)methyl)-4R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts

Rud

Kaplaushenko

Yurchenko

2018

ZMJ

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“…markedly affected the activity of these compounds[15][16][17][18][19]. Metal-complex dyes are very versatile in terms of applications.…”

mentioning

confidence: 99%

Synthesis, spectral characterization, thermal analysis and electrochemistry properties of Ni(II) complexes derived from azo dyes

Arabahmadi

2015

J Therm Anal Calorim

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Three new complexes of nickel(II) prepared from azo-containing salicylaldimine ligands with nickel(II) acetate. The prepared complexes were characterized by IR, UV-Vis, elemental analysis, fluorescence and 1 H NMR spectroscopy. Thermal properties and decomposition possibilities of nickel(II) complexes are suggested. The interpretation of all thermal decomposition stages has been evaluated. Electronic structure of the complexes indicated that the absorption between 450 and 528 nm, which were the lowest energy transfers in the complexes, was attributed to the metal-ligand charge-transfer transitions. The redox behavior of nickel(II) complexes studied by cyclic voltammetry. All the synthesized complexes can serve as potential photoactive materials as indicated from their characteristic fluorescence properties.

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Role of Metallodrugs in Medicinal Inorganic Chemistry

Kumar

Kant

et al. 2020

Advances in Metallodrugs

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Thermal behaviour of some novel antimicrobials based on complexes with a Schiff base bearing 1,2,4-triazole pharmacophore

Cited by 25 publications

References 49 publications

Synthesis, physical and chemical properties of 2-((5-(hydroxy(phenyl)methyl)-4R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts

Synthesis, physical and chemical properties of 2-((5-(hydroxy(phenyl)methyl)-4R-4H-1,2,4-triazole-3-yl)thio)acetic acids and its salts

Synthesis, spectral characterization, thermal analysis and electrochemistry properties of Ni(II) complexes derived from azo dyes

Role of Metallodrugs in Medicinal Inorganic Chemistry

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