Thermal behaviour and stability in Olanzapine

Quantification of olanzapine polymorphs using powder X-ray diffraction technique

“….4 • C. OLZ form I and II were found to be anhydrous as they exhibited no weight loss due to desolvation during TGA. In both forms, mass loss takes place after melting peak, and these results were concordant to previously reported study [13]. Similar pattern was observed under HSM where form I showed melting at 179 • C and recrystallization into plate-shaped crystals at 186 • C that finally melted at 193 • C. Form II directly melted at a temperature of about 195 • C. The region of 1500-1000 cm −1 is important in case of FTIR for identification of form II that showed unique -CH 2 band at 1470 cm −1 .…”

Thermal stability of aripiprazole monohydrate investigated by Raman spectroscopy

“…Since Raman scattering measurement can be easily performed under extreme conditions (temperature, pressure, moisture, etc. ), this experimental method is particularly suitable to investigate structural transformations in APIs like polymorphic transitions and solvatation/desolvatation processes [17][18][19].…”

“…The application of this technique to monitor the solid phase during polymorphic and pseudopolymorphic phase transi- tions has been described in recent publications [17][18][19]. The aim of this work is to investigate in situ the dehydration process of the aripiprazole hydrate (H 1 ) by using Raman scattering.…”

Polymorphism and Solvatomorphism 2005

“…The stability and thermal characteristics of two anhydrate and a water/dimethylsulfoxide solvatomorph of olanzapine have been studied, with structural studies confirming the presence of a rigid dimeric species as being the structural building unit in all known phases 50. Four crystal forms of venlafaxine hydrochloride (three anhydrates and a hydrate/alcoholate) and an amorphous material have been studied, and the phase transformations among these recorded 51.…”