Thermal Behavior of Polymers in Solid-State

Butarbutar, Maria Elvina Tresia; Chaerunisaa, Anis Yohana

doi:10.58920/sciphar01010008

Cited by 1 publication

(2 citation statements)

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Section: Resultsmentioning

confidence: 99%

“…The thermal behavior of polymers is directly related to the bond energies in the polymer structure, involving noncovalent or/and covalent interactions, among others. Moreover, the parameters associated with the polymer structure, such as the molecular weight, the nature of functional groups, and the degree of branching and crosslinking, substantially alter its thermal behavior [39,40]. Practically, these microcrystalline regions are physical cross-linkages, resulting from favorable attractive intra and intermolecular interactions, mainly mediated by hydrogen bonding between the polymer chains of the kefiran-CS polymer.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

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Development of Conjugated Kefiran-Chondroitin Sulphate Cryogels with Enhanced Properties for Biomedical Applications

et al. 2023

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Hydrogels based on natural polysaccharides can have unique properties and be tailored for several applications, which may be mainly limited by the fragile structure and weak mechanical properties of this type of system. We successfully prepared cryogels made of newly synthesized kefiran exopolysaccharide-chondroitin sulfate (CS) conjugate via carbodiimide-mediated coupling to overcome these drawbacks. The freeze-thawing procedure of cryogel preparation followed by lyophilization is a promising route to fabricate polymer-based scaffolds with countless and valuable biomedical applications. The novel graft macromolecular compound (kefiran-CS conjugate) was characterized through 1H-NMR and FTIR spectroscopy—which confirmed the structure of the conjugate, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)—which mirrored good thermal stability (degradation temperature of about 215 °C) and, finally, gel permeation chromatography–size exclusion chromatography (GPC-SEC)—which proved an increased molecular weight due to chemical coupling of kefiran with CS. At the same time, the corresponding cryogels physically crosslinked after the freeze-thawing procedure were investigated by scanning electron microscopy (SEM), Micro-CT, and dynamic rheology. The results revealed a prevalent contribution of elastic/storage component to the viscoelastic behavior of cryogels in swollen state, a micromorphology with micrometer-sized open pores fully interconnected, and high porosity (ca. 90%) observed for freeze-dried cryogels. Furthermore, the metabolic activity and proliferation of human adipose stem cells (hASCs), when cultured onto the developed kefiran-CS cryogel, was maintained at a satisfactory level over 72 h. Based on the results obtained, it can be inferred that the newly freeze-dried kefiran-CS cryogels possess a host of unique properties that render them highly suitable for use in tissue engineering, regenerative medicine, drug delivery, and other biomedical applications where robust mechanical properties and biocompatibility are crucial.

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Section: Resultsmentioning

confidence: 99%

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%