Abstract:The thermal behavior of two polymorphic forms of rifampicin was studied by DSC and TG/DTG. The thermoanalytical results clearly showed the differences between the two crystalline forms. Polymorph I was the most thermally stable form, the DSC curve showed no fusion for this species and the thermal decomposition process occurred around 245 °C. The DSC curve of polymorph II showed two consecutive events, an endothermic event (T peak = 193.9 °C) and one exothermic event (T peak = 209.4 °C), due to a melting proces… Show more
“…The peak temperature of the DTG was identified as the highest weight loss temperature. By using the Ozawa method, the activation energy for the decomposition (Eap) was determined which represents the thermal stability of the rubber . The crosslink density of the GO/FKM and RGO/FKM was investigated by the equilibrium swelling test according to ASTM D6814.…”
“…The peak temperature of the DTG was identified as the highest weight loss temperature. By using the Ozawa method, the activation energy for the decomposition (Eap) was determined which represents the thermal stability of the rubber . The crosslink density of the GO/FKM and RGO/FKM was investigated by the equilibrium swelling test according to ASTM D6814.…”
“…Według wytycznych w niej zamieszczonych badanie czystości powinno spełniać następujące kryteria: -masa próbki 1-3 mg z dokładnością do 0,01 mg; -przepływ azotu 15-50 mL/min; -ogrzewanie próbki z szybkością 0,3-0,7°C/min 25°C poniżej temperatury topnienia; -minimum 200 punktów pomiarowych w zakresie topnienia; -ubytek masy próbki po pomiarze mniejszy niż 1%; -tygle powinny zostać wykonane z materiałów o dużej przewodności cieplnej i niereagujących z próbką; -pomiar pola powierzchni endotermy wyznaczany w przedziale 10-50% całkowitej powierzchni piku; -zanieczyszczenia muszą być rozpuszczalne w facie ciekłej; -mieszanina występuje w fazie ciekłej w postaci jednego lub więcej eutektyków. Do oznaczenia czystości mesylanu imatynibu zostało zastosowane równanie van't Hoffa, które przedstawia zależność między obniżeniem temperatury topnienia substancji czystej pod wpływem zawartych w niej zanieczyszczeń a stężeniem tych zanieczyszczeń [26,27]: Rycina 3 przedstawia przykładową krzywą DSC zarejestrowaną w zakresie wytyczonym zgodnie z normą ASTM E928-08 (linia czerwona).…”
the study were compared with purity presented in the certificates of the substance. Additionally, an influence of both the heating rate and mass changes of samples on determined value of imatinib mesilate purity, was investigated.
“…The thermal behavior of the compressed implants in the form of tablets was evaluated by using Differential Scanning Calorimeter (DSC) and thermal gravimetric analysis (TGA). The required quantity of the samples (100 ± 1 mg) was placed in platinum crucible with a specified heating range of 25-500°C with a heating rate of 10 C/min [9].…”
Section: Thermodynamic Behavior Of the Ketorolac-loaded Implantsmentioning
This present experiment deals with a formulation of novel drug delivery system of chitosan implants to modulate the release of ketorolac through the fabrication of subcutaneous implant. The implants were prepared by compression technique. The chemical stability and the characteristic features of surface morphology of the implants were confirmed by using FTIR and SEM. The thermodynamic behavior of the novel implants was investigated by using DSC/TGA. The loading capacity of Ketorolac into chitosan implants was also evaluated. The release kinetic parameters were studied in dissolution media of phosphate buffer solution (PBS). The results find that the final formulation maintains chemical stability of the drug. The morphological features of the implant confirmed uniform inclusion and distribution of ketorolac into the chitosan matrix with an evidence of porous structure. The drug release pattern of the Ketorolac exhibited controlled release behavior from chitosan implants up to 45 d governed mainly by drug diffusion mechanism. The formulated of novel implants have shown a great potential in the long term subcutaneous delivery of ketorolac.
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