Thermal and epithermal neutrons in the treatment of neoplasms. Technical progress report, May 1, 1972--April 30, 1973

Abstract

We are continuing to investigate fully the biological properties of certain oxidized B^H^SH""^ derivatives and polyhedral borane phosphates which have demonstrated extremely enc ouraging tumor binding capacities in our rat tumor model. This is being carried out with the view to evaluating their suitability on which to base a boron-10 neutron capture therapy trial in man. Biological testing will inc lude appraisal in a rat model gliomas histologically similar to common h- .-'an gliomas, and in patients with gliomas in whom boron concentrations in the relevant tissues will be determined during craniotomies for their tumors.