Thermal ablation to relieve pain from metastatic bone disease: a systematic review

Gennaro, Nicolò; Sconfienza, Luca Maria; Ambrogi, Federico; Boveri, Sara; Lanza, Ezio

doi:10.1007/s00256-018-3140-0

Cited by 47 publications

(42 citation statements)

References 59 publications

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“…Over the past decade, minimally invasive or noninvasive image-guided percutaneous thermal ablation techniques, such as radiofrequency ablation, have become a well-established treatment modality and are now widely used as the primary or secondary treatment of bone tumor pain in patients who cannot undergo surgery or in whom radiation therapy has failed (14,15). Advantages of cryoablation over other thermal ablation techniques (radiofrequency or microwave ablation) include the ability to directly visualize the ablation margin, customize the size and shape of the ablation zones to match the target lesion, decrease intraprocedural and postprocedural pain, and shorten postprocedure hospital stays (13,(16)(17)(18).…”

mentioning

confidence: 99%

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

Jennings¹,

Prologo²,

Garnon³

et al. 2021

Radiology: Imaging Cancer

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To assess the clinical effectiveness of cryoablation for palliation of painful bone metastases. Materials and Methods: MOTION (Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases) (ClinicalTrials.gov NCT 02511678) was a multicenter, prospective, single-arm study of adults with metastatic bone disease who were not candidates for or had not benefited from standard therapy, that took place from February 2016 to March 2018. At baseline, participants rated their pain using the Brief Pain Inventory-Short Form (reference range from 0 to 10 points); those with moderate to severe pain, who had at least one metastatic candidate tumor for ablation, were included. The primary effectiveness endpoint was change in pain score from baseline to week 8. Participants were followed for 24 weeks after treatment. Statistical analyses included descriptive statistics and logistic regression to evaluate changes in pain score over the postprocedure follow-up period. Results: A total of 66 participants (mean age, 60.8 years 6 14.3 [standard deviation]; 35 [53.0%] men) were enrolled and received cryoablation; 65 completed follow-up. Mean change in pain score from baseline to week 8 was 22.61 points (95% CI: 23.45, 21.78). Mean pain scores improved by 2 points at week 1 and reached clinically meaningful levels (more than a 2-point decrease) after week 8; scores continued to improve throughout follow-up. Quality of life improved, opioid doses were stabilized, and functional status was maintained over 6 months. Serious adverse events occurred in three participants. Conclusion: Cryoablation of metastatic bone tumors provided rapid and durable pain palliation, improved quality of life, and offered an alternative to opioids for pain control.

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mentioning

confidence: 99%

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

Jennings¹,

Prologo²,

Garnon³

et al. 2021

Radiology: Imaging Cancer

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“…In man, MWA has been used to palliate metastatic bone lesions. In 11 studies with a total of 364 human patients, lesion pain was reduced by up to 95% by 12 weeks after MWA 38 . In another retrospective study 39 of 35 human patients with 37 bone metastases, MWA with polymethylmethacrylate cementoplasty was performed safely and effectively in vertebral, femoral, and acetabular lesions.…”

Section: Discussionmentioning

confidence: 99%

“…No information is currently available regarding long‐term complications of MWA in dogs. In a meta‐analysis of thermal ablation, Ringe et al 38 found that no people who underwent MWA as a palliative treatment for painful bone metastases exhibited complications. We can only speculate regarding the long‐term safety in dogs on the basis of studies in people because there is no current literature in which long‐term safety has been investigated.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of microwave ablation for local treatment of dogs with distal radial osteosarcoma: A pilot study

et al. 2020

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Objective: To evaluate the feasibility and safety of microwave ablation (MWA) as a modality to induce tumor necrosis within distal radial osteosarcoma (OSA). Study design: Pilot study. Animals: Six client-owned dogs with distal radius OSA confirmed by cytological examination. Methods: Dogs underwent computed tomography for surgical planning before general anesthesia for fluoroscopy-guided ablation. Computed tomography was repeated 48 hours after MWA, before amputation. The ablated tumor was evaluated with histopathology. Results: Six dogs underwent MWA of distal radius OSA. A lower power setting (30 W) was selected for the first two dogs to avoid collateral soft tissue damage. The power was increased to 75 W for the last four dogs. The temperature was maintained between 45 C and 55 C (113 F-131 F) at the bone/soft tissue interface. Tumor necrosis varied between 30% and 90% (median, 55%) according to histopathology. No intraoperative or periprocedural complications were observed. Conclusion: Microwave ablation induced variable tumor necrosis and did not induce immediate postablation complications in these six dogs with distal radius OSA. Clinical significance: These results justify further evaluation of MWA as a potential modality to treat primary bone lesions in dogs.

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“…Data evaluating microwave ablation, laser ablation and HIFU (high intensity focused ultrasound) in osseous metastasis is limited [58,59] (Table 3). A recent systematic review of the different TA modalities, found no compelling indication of superiority of one technique over the others [60].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The Pain Crisis: Interventional Radiology's Role in Pain Management

Fletcher

Moore

Stensby

et al. 2021

American Journal of Roentgenology

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The publication of this Accepted Manuscript is provided to give early visibility to the contents of the article, which will undergo additional copyediting, typesetting, and review before it is published in its final form. During the production process, errors may be discovered that could affect the content of the Accepted Manuscript. All legal disclaimers that apply to the journal pertain. The reader is cautioned to consult the definitive version of record before relying on the contents of this document.

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Thermal ablation to relieve pain from metastatic bone disease: a systematic review

Cited by 47 publications

References 59 publications

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

Evaluation of microwave ablation for local treatment of dogs with distal radial osteosarcoma: A pilot study

The Pain Crisis: Interventional Radiology's Role in Pain Management

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