There is no rationale to still rely on outdated, biased tools for quantitative morphology in pulmonary research

Stereology: a bridge to a better understanding of lung structure and function

“…This is particularly suitable for the lung, as it can be applied to structures that are inhomogeneous or cannot be assumed to be homogeneous. Despite this and the subsequent developments made towards obtaining unbiased quantitative data of inhomogeneous structures, such as lung parenchyma and the bronchial tree, stereology has been used less in pulmonary research than in other fields.In recent years, the European Respiratory Society (ERS) has organised two courses dedicated to quantitative morphology in pulmonary research, followed by a series of articles in one issue of the European Respiratory Review which offered insight into the theoretical principles and practical applications of design-based stereology to graduate students and scientists [7][8][9][10][11][12][13]. …”

“…In recent years, the European Respiratory Society (ERS) has organised two courses dedicated to quantitative morphology in pulmonary research, followed by a series of articles in one issue of the European Respiratory Review which offered insight into the theoretical principles and practical applications of design-based stereology to graduate students and scientists [7][8][9][10][11][12][13].…”