Consider a finite collection {T1, . . . , TJ } of differential operators with constant coefficients on T n (n ≥ 2) and the space of smooth functions generated by this collection, that is, the space of functions f such that Tjf ∈ C(T n ), 1 ≤ j ≤ J. We prove that if there are at least two linearly independent operators among their senior parts (relative to some mixed pattern of homogeneity), then this space does not have local unconditional structure. This fact generalizes the previously known result that such spaces are not isomorphic to a complemented subspace of C(S).