There is an impairment in time perception of patients with multiple sclerosis

Hüzmeli, Esra Doğru; Duman, Taşkın

doi:10.1080/08990220.2021.1879777

Cited by 2 publications

(5 citation statements)

References 27 publications

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“…Our results indicate that this model cannot make an accurate prediction of this disease unless there is a compensatory mechanism that led them to overestimate the time with a slow clock or the disease is accelerating their clock. Dogru-Huzmeli et al have shown overestimating time in multiple sclerosis patients, and while they found higher scores in estimation and lower scores in production for PwMS, we found higher scores in both estimation and production of time in PwMS than healthy individuals [ 8 ]. Compared to other medical conditions, there is increasing evidence that Parkinson’s disease patients underestimate time.…”

Section: Discussionmentioning

confidence: 49%

“…In addition to certain synthetic substances and herbs, several medical conditions can alter the perception of time and have led to a more accurate definition of the temporal processing mechanism. Neurodegenerative diseases such as Parkinson’s and Alzheimer’s have been shown that could alter time perception [ 2 , 8 , 9 , 14 , 15 , 17 , 31 ]. In Parkinson’s disease, time perception impairment is shown to be associated with dopaminergic system disturbance [ 2 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the effects of multiple sclerosis on time perception ability have yet to be explored [ 8 , 13 ]. Multiple sclerosis is a neurodegenerative disorder characterized by acquired distributed (in time and location) demyelination in the central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

“…The fronto-striatal circuitry which seems to be a vital component of the internal clock circuit and responsible for temporal information processing is damaged in multiple sclerosis [ 12 , 19 ]. Since enough information about time perception ability in PwMS is missing and lacks the concept of time as a cognitive entity, and related factors like education and gender differences are not yet cleared [ 8 , 13 ],a set of tasks and methods are employed for explicating different aspects of this cognitive performance and probable factors affecting it. Our initial hypothesis based on that neuronal conduction slowing down due to a damaged myelin sheath can affect internal clock speed.…”

Section: Introductionmentioning

confidence: 99%

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Time perception impairment in multiple sclerosis patients: a survey on internal clock model

Echreshavi

Shakerian

Shahvandi

et al. 2022

Neurosci Behav Physi

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Time perception is known as a mental ability to discern time. Although relative nature of time leaves its numerous aspects undefined, several models have been developed to describe temporal information processing in the brain as well as several areas of the brain have shown to be involved. Time perception alteration has been reported in several neurological conditions; however, the effect of multiple sclerosis (MS) on time perception has yet to be explained. In this study, we aimed to investigate the domains of temporal processing involved in patients with MS and the probable factors affecting it, such as the location of brain demyelinating plaques and gender. Two groups of participants (MS: n = 27 (8 men, 19 women), mean age = 33.85; control: n = 30 (10 men, 20 women), mean age = 28.46) were asked to perform quadruplet time perception tasks (prospective time estimation, duration discrimination, temporal reproduction, and paced motor timing) designed with a software program. Patients with MS had significantly higher scores in time estimation ( p < 0.01) and duration discrimination ( p < 0.001, in 100-ms interval; p < 0.05, in 1000-ms interval), indicating that MS patients overestimate the time. Since a slower internal clock for MS patients was expected as a result of axonal demyelination, these results suggest the time overestimation in patients with MS which is in contrast with the internal clock model. It means that a slow internal clock causes underestimating and perceiving the time slower.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Time perception impairment in multiple sclerosis patients: a survey on internal clock model

Echreshavi

Shakerian

Shahvandi

et al. 2022

Neurosci Behav Physi

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show abstract

“…Altered time perception has been demonstrated in patients with schizophrenia ( 41 ), depression ( 42 , 43 ), traumatic brain injury ( 44 ), attention-deficit/hyperactivity disorder (AHDH) ( 45 ), autism ( 46 ), Huntington's disease ( 47 ), multiple sclerosis ( 48 ), and Alzheimer's disease ( 49 ). However, this is the first time that an altered time perception has been characterized in vestibular patients.…”

Section: Discussionmentioning

confidence: 99%

Cognitive and balance functions of astronauts after spaceflight are comparable to those of individuals with bilateral vestibulopathy

Clément,

Kuldavletova,

Macaulay

et al. 2023

Front. Neurol.

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IntroductionThis study compares the balance control and cognitive responses of subjects with bilateral vestibulopathy (BVP) to those of astronauts immediately after they return from long-duration spaceflight on board the International Space Station.MethodsTwenty-eight astronauts and thirty subjects with BVP performed five tests using the same procedures: sit-to-stand, walk-and-turn, tandem walk, duration judgment, and reaction time.ResultsCompared to the astronauts' preflight responses, the BVP subjects' responses were impaired in all five tests. However, the BVP subjects' performance during the walk-and-turn and the tandem walk tests were comparable to the astronauts' performance on the day they returned from space. Moreover, the BVP subjects' time perception and reaction time were comparable to those of the astronauts during spaceflight. The BVP subjects performed the sit-to-stand test at a level that fell between the astronauts' performance on the day of landing and 1 day later.DiscussionThese results indicate that the alterations in dynamic balance control, time perception, and reaction time that astronauts experience after spaceflight are likely driven by central vestibular adaptations. Vestibular and somatosensory training in orbit and vestibular rehabilitation after spaceflight could be effective countermeasures for mitigating these post-flight performance decrements.

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There is an impairment in time perception of patients with multiple sclerosis

Cited by 2 publications

References 27 publications

Time perception impairment in multiple sclerosis patients: a survey on internal clock model

Time perception impairment in multiple sclerosis patients: a survey on internal clock model

Cognitive and balance functions of astronauts after spaceflight are comparable to those of individuals with bilateral vestibulopathy

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