There is a significant relationship between morning blood pressure surge and increased abdominal aortic intima–media thickness in hypertensive patients

Koç, Ayşe Selcan; Görgülü, Feride Fatma; Dönmez, Yurdaer; İçen, Yahya Kemal

doi:10.1007/s10396-018-0877-y

Cited by 7 publications

(11 citation statements)

References 38 publications

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“…AA-IMT measurement can be used to detect the development of early atherosclerosis due to the initial onset of atherosclerosis in the distal abdominal aorta [3][4][5]. There are limited studies regarding the usage of AA-IMT in patients with coronary artery disease (CAD) risk factors [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Aortic intima-media thickness can be used to determine target organ damage in adult patients with coronary artery disease risk factors

Bulut¹,

Acele²,

Dönmez³

et al. 2019

Arch Med Sci Atheroscler Dis

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Introduction: We aimed to evaluate the relationship between abdominal aortic intima-media thickness (AA-IMT) and thoracic aortic intima-media thickness (TA-IMT) values and to investigate their relationship with common carotid intima-media thickness (CC-IMT) in patients with coronary artery disease (CAD) risk factors. Material and methods: This study included 100 patients who underwent transesophageal echocardiography (TEE) examination for different reasons with at least one CAD risk factor. CC-IMT, AA-IMT, and TA-IMT values were measured. Patients with CC-IMT > 0.9 mm were considered as having increased CC-IMT. Patients were divided into two groups with and without increased CC-IMT. Results: Mean AA-IMT and TA-IMT values of all patients were 1.55 ±0.27 mm and 1.39 ±0.25 mm, respectively. In patients with increased CC-IMT, blood pressure, hyperlipidemia and hypertension frequency, creatinine, total and low-density lipoprotein (LDL) cholesterol, triglyceride, high-sensitivity C-reactive protein (hs-CRP) and uric acid levels, AA-IMT and TA-IMT values were higher, while the high-density lipoprotein (HDL) cholesterol level was lower than the normal CC-IMT group. AA-IMT, systolic blood pressure (SBP), total and HDL cholesterol levels independently determined the patients with CC-IMT > 0.9 mm. Each 0.1 mm increase in AA-IMT value was found to increase the probability of having CC-IMT > 0.9 mm. In addition, linear regression analysis showed that CC-IMT was closely and independently related to AA-IMT (p < 0.001 and β = 0.599). When the cutoff value for AA-IMT was taken as 1.5 mm, it determined the patients with CC-IMT > 0.9 mm with 86% sensitivity and 82% specificity. Conclusions: The AA-IMT value was found to be higher than TA-IMT in the same patient. Also it was found that AA-IMT was more closely related to CC-IMT.

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Section: Introductionmentioning

confidence: 99%

“…However, recently published articles have reported that AA-IMT may be easily measured with high-resolution devices [8][9][10][11]. Another important and atherosclerotic process-related IMT measurement region is thoracic aortic IMT (TA-IMT).…”

Section: Introductionmentioning

confidence: 99%

Aortic intima-media thickness can be used to determine target organ damage in adult patients with coronary artery disease risk factors

Bulut¹,

Acele²,

Dönmez³

et al. 2019

Arch Med Sci Atheroscler Dis

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“…When the presence of collagen in the vein wall is examined; there are thin collagen fibril bundles in the subendothelial intima layer, more in the tunica media layer among the smooth muscle cells and much in the adventitia layer 21 . The most frequent causes of death in patients with acromegaly is are CV events and CV mortality is doubled compared to the normal population [1][2][3][4] . Therefore, it is important to diagnose these patients with increasing IMT at the stage of subclinical or asymptomatic atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…The most important problem about the AIMT assessment in research studies is that AIMT measurement cannot be done clearly and there are not enough devices that provide adequate tissue penetration 22,23 . However, this measurement can be done clearly after 6 hours of fasting and in non-obese patients 2 . Atherosclerosis begins with fatty streaks in childhood, which can be detected early by sensitive vascular imaging techniques 16,24 .…”

Section: Discussionmentioning

confidence: 99%

Akromegali hastalarında aort intima media kalınlığı artmıştır ve insülin benzeri büyüme faktörü-1 düzeyi ile bağımsız olarak ilişkilidir

Sümbül

Demirtaş

2019

Cukurova Medical Journal

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In our article, we aimed to identify whether there is an increase in intima-media thickness (IMT) measured from the abdominal aorta in patients with acromegaly and to identify the parameters closely related to the aortic IMT (AIMT). Materials and Methods: 52 patients with acromegaly and 46 healthy controls were included. For all participants, all the necessary laboratory tests were done for acromegaly. On vascular ultrasound examination, the internal carotid IMT, common-carotid IMT, and aortic IMT (AIMT) were measured. The study population was divided into 3 different groups; control group (Group I), acromegaly patients in remission (Group II) and acromegaly patients with active disease (group-III). Results: The incidence of hypertension, diabetes, and smoking was higher in Group-II-III than Group I. Insulin-like growth factor-1 (IGF-1) levels were increased from Group I to III and there was a significant difference between all groups. Common-carotid IMT and internal carotid IMT values were not significantly different between the groups. The AIMT value in Group III patients was statistically higher than the other two groups. The AIMT was similar between Groups I to II. Only the IGF-1 level was found to be independently associated with AIMT. Conclusion: In patients with active acromegaly disease, AIMT is significantly elevated without elevation of carotid IMT, and AIMT is independently associated with serum IGF-1 levels. AIMT could be a useful study to show the presence of early subclinical atherosclerosis in acromegaly patients.

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“…The common carotid artery intima-media thickness (IMT) and abdominal aortic IMT were calculated as previously described. (28) Grey-scale B-mode US evaluation was first performed to assess kidney sizes, cortical thickness and parenchyma echogenicity. Kidney length was measured in the coronal plane from the upper pole to the lower pole of the kidney.…”

Section: Methodsmentioning

confidence: 99%

Renal cortical stiffness is markedly increased in pre-diabetes mellitus and associated with albuminuria

Sümbül¹,

Koç²,

Gulumsek³

2020

smedj

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Introduction:We aimed to investigate changes in renal cortical stiffness (CS) in Type II diabetes mellitus (DM) and pre-DM patients compared to subjects with normal glucose metabolism (NGM), as well as the usefulness of renal CS to determine the presence of nephropathy.Methods: This study included 125 individuals with NGM, pre-DM and Type II DM. Routine laboratory data was obtained, and micro-and macrovascular involvement were investigated.Urinary albumin-creatinine ratio (ACR) was measured for urinary albuminuria detection. In addition to routine renal ultrasonography, CS was measured using renal elastography. Results:Among the included patients, 42, 40 and 43 patients had NGM, pre-DM and Type II DM, respectively, with prevalence of nephropathy of 5%, 15% and 33%, respectively. Carotid and aortic intima-media thickness (IMT), renal width, and CS were found to be higher in the pre-DM and Type II DM groups than the NGM group. Aortic-IMT, renal width and urinary ACR levels were independently associated with CS. Patients with nephropathy were found to have a higher CS value than those without nephropathy (8.72 ± 1.67 kPa vs. 10.60 ± 1.74 kPa, p = 0.001). In ROC analysis, when the cutoff value for CS was taken as 9.2 kPa, renal CS predicted the possibility of nephropathy with 78.9% sensitivity and 71.4% specificity.Conclusion: CS values are significantly higher in patients with impaired glucose metabolism.We recommend CS measurement as part of routine screening of nephropathy in patients with pre-DM and newly diagnosed Type II DM.

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There is a significant relationship between morning blood pressure surge and increased abdominal aortic intima–media thickness in hypertensive patients

Cited by 7 publications

References 38 publications

Aortic intima-media thickness can be used to determine target organ damage in adult patients with coronary artery disease risk factors

Aortic intima-media thickness can be used to determine target organ damage in adult patients with coronary artery disease risk factors

Akromegali hastalarında aort intima media kalınlığı artmıştır ve insülin benzeri büyüme faktörü-1 düzeyi ile bağımsız olarak ilişkilidir

Renal cortical stiffness is markedly increased in pre-diabetes mellitus and associated with albuminuria

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