There Are Indeed More Left-Handers Within the Autism Spectrum Disorder Compared with in the General Population, but the Many Mixed-Handers Is the More Interesting Finding

Rysstad, Anne Langseth; Pedersen, Arve Vorland

doi:10.1007/s10803-018-3553-6

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…In the literature, missing resources and overstrained staff teaching children with ASD were reported ( 76 ). Our data show in line with the literature less right-handedness and more left-handedness in children with ASD ( 77 ). In our study, parents of adolescents with ASD reported more complications for the child in transition to primary school, more internalizing behavior, more externalizing behavior, more difficulties with teachers and peers, more loneliness, and less school acceptance, less firm friends, and less invitations to birthdays ( Figure 5B ).…”

Section: Discussionsupporting

confidence: 93%

Family and Developmental History of Individuals With Autism Spectrum Disorder: Importance of the Clinical Diagnostic Interview for Diagnosis in Adolescents. An Explorative Study

et al. 2021

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Background: Diagnosis of autism spectrum disorder (ASD) can be made early in childhood, but also later in adolescence or adulthood. In the latter cases, concerns about an individual's behavior typically lead to consultation of a mental health professional (MHP). As part of the initial clinical examination by the MHP, a clinical diagnostic interview is performed, in order to obtain the patient's history, and may lead to the hypothesis of ASD. We were here interested to study family and developmental history as key parts of the patient's history. The aim of the study was to investigate empirical differences between adolescents with ASD and adolescent control persons in family and developmental history.Method: Clinical diagnostic interview items addressing family and developmental history were adopted from their regular use at several university hospitals and in leading textbooks. Parents of male adolescents with normal intelligence and an ASD diagnosis (n = 67) and parents of male adolescents without psychiatric diagnosis (n = 51) between the age of 12 and 17 years were investigated. Data were operationalized into three categories: 0 = normal behavior, 1 = minor pathological behavior, and 2 = major pathological behavior. Differences were analyzed by multiple t-test of two-way ANOVA.Results: Adolescents with ASD expressed a profile of items significantly differing from control persons. Comparison of significant items with the empirical ASD literature indicated robust accordance.Conclusions: Our findings support the importance and feasibility of the clinical diagnostic interview of family and developmental history for initiation of the diagnostic process of ASD in adolescents.

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Section: Discussionsupporting

confidence: 93%

Family and Developmental History of Individuals With Autism Spectrum Disorder: Importance of the Clinical Diagnostic Interview for Diagnosis in Adolescents. An Explorative Study

et al. 2021

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“…Resting-state functional MRI data of people with ASD have also shown a generally rightward shift of asymmetry involving various functional networks of brain regions 21 . In addition, people with ASD have a higher rate of left-handedness than the general population 20,22,23 . Furthermore, an electroencephalography study reported that infants at high risk for ASD showed more rightward than leftward frontal alpha asymmetry at rest 24 .…”

Section: Introductionmentioning

confidence: 99%

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Postema

Rooij²,

Anagnostou³

et al. 2019

Nat Commun

224

186

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Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

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“…Resting-state functional MRI of people with ASD has also suggested a rightward shift of asymmetry that involves various functional networks (Cardinale, et al, 2013). People with ASD have a higher rate of left-handedness than the general population (Lindell and Hudry, 2013;Markou, et al, 2017;Rysstad and Pedersen, 2018). In addition, brain structural imaging studies have reported altered hemispheric asymmetry in ASD, including studies of white matter tracts (Carper, et al, 2016;Conti, et al, 2016;Joseph, et al, 2014), grey matter volume, surface and thickness (Dougherty, et al, 2016;Floris, et al, 2016).…”

Section: Autism Spectrum Disordermentioning

confidence: 99%

Mapping brain asymmetry in health and disease through the ENIGMA consortium

Kong¹,

Postema²,

Guadalupe³

et al. 2019

Preprint

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Left-right asymmetry of the human brain is one of its cardinal features, and also a complex, multivariate trait. Decades of research have suggested that brain asymmetry may be altered in psychiatric disorders. However, findings have been inconsistent and often based on modest sample sizes. There are also open questions surrounding which structures are asymmetrical on average in the healthy population, and how variability in brain asymmetry relates to basic biological variables such as age and sex. Over the last four years, the ENIGMA-Laterality Working Group has published six studies of brain structural asymmetry based on total sample sizes of between roughly 3,500 and 17,000 individuals, which were between one and two orders of magnitude larger than those published in previous decades. A population-level mapping of average brain asymmetry was achieved, including an intriguing fronto-occipital gradient of cortical thickness asymmetry in healthy brains. ENIGMA’s multi-dataset approach also supported an empirical illustration of reproducibility of hemispheric differences across datasets. Effect sizes were estimated for brain asymmetry based on large, international, samples in relation to age, sex, handedness, and brain volume, as well as for three psychiatric disorders: Autism Spectrum Disorder was associated with subtly reduced asymmetry of cortical thickness at regions spread widely over the cortex; Pediatric Obsessive-Compulsive Disorder was associated with altered subcortical asymmetry; Major Depressive Disorder was not significantly associated with changes of asymmetry. Ongoing studies are examining brain asymmetry in other disorders. Moreover, a groundwork has been laid for possibly identifying shared genetic contributions to brain asymmetry and disorders.

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There Are Indeed More Left-Handers Within the Autism Spectrum Disorder Compared with in the General Population, but the Many Mixed-Handers Is the More Interesting Finding

Cited by 11 publications

References 10 publications

Family and Developmental History of Individuals With Autism Spectrum Disorder: Importance of the Clinical Diagnostic Interview for Diagnosis in Adolescents. An Explorative Study

Family and Developmental History of Individuals With Autism Spectrum Disorder: Importance of the Clinical Diagnostic Interview for Diagnosis in Adolescents. An Explorative Study

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Mapping brain asymmetry in health and disease through the ENIGMA consortium

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