Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease

Marino, G.; Moraci, Marco; Armenia, Emilia; Orabona, Consiglia; Renato, Sergio; Sena, Gabriele De; Capuozzo, Vincenza; Barbarisi, Manlio; Rosso, Francesco; Giordano, Giovanni; Iovino, Francesco; Barbarisi, Alfonso

doi:10.1016/j.jss.2013.05.024

Cited by 128 publications

(91 citation statements)

References 13 publications

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“…Small case series applying this approach in chronic cutaneous wounds have similarly been published. [18][19][20] Despite the advances in cell-based therapies, many challenges still remain regarding safety, efficacy, and robustness of various delivery methods. Several approaches (e.g., fibrin spray, systemic, local injection, topical delivery, and scaffold delivery) have been tested for delivery of stem/progenitor cells to acute and chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Foubert

Gonzalez

Teodosescu

et al. 2016

Advances in Wound Care

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Section: Introductionmentioning

confidence: 99%

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Foubert

Gonzalez

Teodosescu

et al. 2016

Advances in Wound Care

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“…ASC can be isolated from small amounts of adipose tissue, efficiently expanded to achieve a very large number after 3 to 4 passages, and have the advantage of low immunogenicity and high multipotency. Their immunmodulatory function, homing and migratory patterns, as well as previous clinical trials, have suggested that these cells are efficient and safe for treating several classes of autoimmune diseases [1][2][3][4].…”

mentioning

confidence: 95%

Effects of autologous adipose-derived stem cell infusion on type 2 diabetic rats

Chen

et al. 2015

Endocr J

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Type 2 diabeTes melliTus (T2DM) accounts for more than 90% of all diabetic patients and is characterized by insulin resistance, hyperglycemia, systemic low-grade inflammation, and relative lack of insulin. Most T2DM patients experience β-cell exhaustion several years after diagnosis, and thus have to accept insulin therapy. However, insulin therapy is inconvenient for patients and does not completely prevent the development of diabetic complications. Stem cells are an attractive option to ameliorate diabetes for its abundant source and potential to acquire glucose-dependent insulin secretory function. Adult stem cells are an especially good candidate for its safety in terms of tumorigenicity and ethical concerns.Adipose-derived stem cells (ASC) have been stud- The effects and possible mechanisms of adipose-derived stem cells (ASC) infusion on type 2 diabetic rats were investigated in this study. Twenty normal male Sprague-Dawley rats were included in normal control group, and 40 male diabetic rats were randomly divided into diabetic control group and ASC group (which received ASC infusion). After therapy, levels of fasting plasma glucose (FPG), HbA1c, serum insulin and C-peptide, recovery of islet cells, inflammatory cytokines, and insulin sensitivity were analyzed. After ASC infusion, compared with diabetic control group, hyperglycemia in ASC group was ameliorated in 2 weeks and maintained for about 6 weeks, and plasma concentrations of insulin and C-peptide were significantly improved (P<0.01). Number of islet β cells and concentration of vWF in islets in ASC group increased, while activity of caspase-3 in islets was reduced. Moreover, concentrations of TNF-α, IL-6 and IL-1β in ASC group obviously decreased (P<0.05). The expression of GLUT4, INSR, and phosphorylation of insulin signaling molecules in insulin target tissues were effectively improved. ASC infusion could aid in T2DM through recovery of islet β cells and improvement of insulin sensitivity. Autologous ASC infusion might be an effective method for T2DM.

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“…Especially there is up to 70% improvement in appearance of scar of ulcer after STG in lower limbs. 14 …”

Section: Colour Of Scarmentioning

confidence: 99%

An intervention study of autologous fat transfer for scar tissue rejuvenation in the setup

Parikh

Darshan

2018

Int Surg J

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Background: There are lot of work going on AFT procedures. This procedure has been taken recent advances nowadays and very helpful in many conditions to rejuvenate and restoration of damaged tissues. The use of autologous fat for soft tissue augmentation seems attractive because of its relatively ubiquitous availability. Autologous fat transfer is a technique shown to be beneficial as a reconstructive procedure for patients with volume loss of tissue due to disease, trauma, and congenital defects.Methods: In the present study, 20 patients were taken as sample size. It is an intervention study. Whole procedure has been taken as day case which included local anaesthesia and patient received all the standard monitoring, medications, safety precautions and care that is provided for any patient undergoing any surgery, including antibiotics, pain medicine and other supportive care as needed. The Autologous fat was harvested by surgeon via syringe aspiration technique with a long atraumatic cannula. After processing, the material was injected immediately under designated skin grafts/scars using a small needle. Scar was cleansed with normal saline and dry dressing is applied for a day. Then patient was discharged on the same day.Results: Results obtained were efficacious with 60 to 80% improvement in all parameters in 15-20 days after the procedure.Conclusions: AFT procedure was found feasible, efficacious and accepted in patients with scar. It brings scar tissue rejuvenation up to great extent.

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Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease

Cited by 128 publications

References 13 publications

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Effects of autologous adipose-derived stem cell infusion on type 2 diabetic rats

An intervention study of autologous fat transfer for scar tissue rejuvenation in the setup

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