Therapy–Related Acute Myeloid Leukaemia Following Concurrent Radiotherapy and Chemotherapy for Humerus Angiosarcoma

Abstract

Abstract:Concurrent chemo-radiotherapy has been an important part of angiosarcoma treatment. Its efficacy has been proven and its adverse effects are well understood. Leukaemogenesis is a potential late complication of ionizing radiation and chemotherapy and is thought to be a direct consequence of mutational events induced by previous therapy. Therapy-related acute myeloid leukaemia in angiosarcoma has rarely been reported in literature. We report a case of therapy related acute myeloid leukaemia in a 48 year old man, 2 years post chemo-radiotherapy for angiosarcoma of the left humerus. The aim of this study is to make physicians aware that this diagnosis should be considered in patients who survive a previous cancer and later presents with health problems.