Therapy of the Postinfectious Irritable Bowel Syndrome: An Update

Iacob, Teodora; Țățulescu, D.; Dumitraşcu, Dan L.

doi:10.15386/cjmed-752

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…The mechanisms by which gut microbes influence the CRC tumorigenesis (Iacob et al, 2017) were actively under study. For examples, researchers have recently learned that the gut microbiota plays a regulatory role in the tumor microenvironment and thus in tissue carcinogenesis (Sohn et al, 2015; Nagy-Szakal et al, 2017; Morgillo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

Pan

et al. 2019

Front. Microbiol.

127

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Colorectal cancer (CRC) is the third most common cancer worldwide. Its incidence is still increasing, and the mortality rate is high. New therapeutic and prognostic strategies are urgently needed. It became increasingly recognized that the gut microbiota composition differs significantly between healthy people and CRC patients. Thus, identifying the difference between gut microbiota of the healthy people and CRC patients is fundamental to understand these microbes' functional roles in the development of CRC. We studied the microbial community structure of a CRC metagenomic dataset of 156 patients and healthy controls, and analyzed the diversity, differentially abundant bacteria, and co-occurrence networks. We applied a modified zero-inflated lognormal (ZIL) model for estimating the relative abundance. We found that the abundance of genera: Anaerostipes, Bilophila, Catenibacterium, Coprococcus, Desulfovibrio, Flavonifractor, Porphyromonas, Pseudoflavonifractor , and Weissella was significantly different between the healthy and CRC groups. We also found that bacteria such as Streptococcus, Parvimonas, Collinsella, and Citrobacter were uniquely co-occurring within the CRC patients. In addition, we found that the microbial diversity of healthy controls is significantly higher than that of the CRC patients, which indicated a significant negative correlation between gut microbiota diversity and the stage of CRC. Collectively, our results strengthened the view that individual microbes as well as the overall structure of gut microbiota were co-evolving with CRC.

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Section: Introductionmentioning

confidence: 99%

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

Pan

et al. 2019

Front. Microbiol.

127

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“…The characteristics of the infectious illness such as diarrhea, abdominal cramps, increased stool frequency, bloody or mucous stools, and positive stool culture and weight loss are potent predictors of long term outcome. The risk of PI-IBS appears to correlate with the severity of the acute enteric infection [12,13]. The above mentioned symptoms are frequently associated with CDI.…”

Section: Discussionmentioning

confidence: 99%

Irritable bowel syndrome after Clostridioides difficile infection

Iacob¹,

Lupşe²,

Dumitraşcu

2020

Preprint

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Background Post-Infectious Irritable Bowel Syndrome (PI-IBS) is a common complication of Clostridioides difficile infection (CDI). The objectives of this study were to asses the risk of PI-IBS following a CDI. We also evaluated if there is a correlation between the onset of PI-IBS and the severity of CDI.Methods The study group consisted of 69 patients consecutively admitted in a tertiary center with an acute gastroenteritis episode, suspected of having a Clostridioides difficile infection. PCR for CDI from feces were performed to assess the infection. The subjects were divided into two groups. A group consisted of patients with CDI and the other group where the CDI was ruled out. The patients were evaluated for PI-IBS 6 months after the episode of CDI by Rome III IBS diagnostic questionnaire and the Bristol Stool Form Scale. In these patients CDI recurrence was ruled out by PCR; patients were retested. Severity of CDI was stratified according to the need for hospitalization or not. Other evaluated parameters for severity at patients were the level of serum creatinin, C-reactive protein (CRP) and white blood cell count (WBC). The questionnaires were paper printed and directly filled in by the subjects.Results The response rate to the questionnaire was 100%. During the course of this study 31 patients died. Out of 38 patients, 37% (14 patients) were diagnosed with CDI. After CDI, 57% (8 patients) developed PI-IBS and 43% (6 patients) where without PI-IBS with a relative risk (RR) of 2.29 (95 % confidence interval CI 0.99 – 5.23), p=0.04. In the group of patients with a severe form of CDI, 90% (9 patients) developed PI-IBS with a RR of 2.72 (95% CI 0.80 – 9.24), p=0.04, compared to the group of patients with light and moderate forms CDI.Conclusion Our study shows that, 6 months after CDI, PI-IBS develops in 57% patients, higher than in the control group where CDI was ruled out by PCR (43%), statitstically significant (p=0.04). The severity of CDI was a risk factor for PI-IBS, 90% of patients with severe forms of CDI developed PI-IBS.

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“…The postinfectious irritable bowel syndrome (PI-IBS) is characterized by the sudden onset of symptoms mentioned in the diagnostic criteria for irritable bowel syndrome that appear after an episode of acute infectious gastroenteritis with by two or more of the following symptoms and findings: diarrhea, vomiting, fever and a positive stool culture result [27]. Pathophysiologic mechanism for PI-BS may be associated with altered motility, increased intestinal permeability, increased numbers of enterochromaffin cells and persistent intestinal inflammation, characterized by increased numbers of T-lymphocytes and mast cells, and increased expression of proinflammatory cytokines.…”

Section: Symptoms and Pathogenesismentioning

confidence: 99%

Irritable bowel syndrome - risk factors, pathogenesis and treatment options

Wójcik

Dąbrowska

Szarpak

et al. 2020

J Educ Health Sport

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Introduction: Irritable bowel syndrome (IBS) is a chronic common gastrointestinal disorder. It contributes to the burden of patients and society due to direct medical costs, lost productivity and also affects the quality of life. The etiology of irritable bowel syndrome is not fully understood which makes it difficult to treat patients more effectively. The aim of the study: The purpose of this systemic review was to collect and analyse current data of risk factors, pathogenesis and treatment options of irritable bowel syndrome. articles in the PubMed and Google Scholar database was carried out using the following keywords: irritable bowel syndrome, gut microbiota, treatment Description of the state of knowledge: Altered gastrointestinal motility, visceral hypersensitivity, post infectious reactivity, brain-gut interactions, alteration in fecal microflora, bacterial overgrowth, food sensitivity, carbohydrate malabsorption, and intestinal inflammation are considered to contribute to the onset of IBS. The biopsychosocial model of illness and disease aims to help understand better the bi-directional relationship between mind and body. Patients suffering from IBS use pharmaceutical treatment but also complementary and alternative medicine. Probiotic and fecal microbiota transplantation are gut microbiota oriented treatment options. Summary: The pathophysiology of IBS is not clear. Alterations in bidirectional brain-gut microbiota interactions are believed to be involved in the pathogenesis of well-known braingut disorders such as IBS. Human microbiome research continues to expand, although it still requires more study.

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Therapy of the Postinfectious Irritable Bowel Syndrome: An Update

Cited by 9 publications

References 28 publications

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

Irritable bowel syndrome after Clostridioides difficile infection

Irritable bowel syndrome - risk factors, pathogenesis and treatment options

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