Therapy of spontaneous metastases with an autologous tumor vaccine in a guinea pig model

Hoover, Herbert; Peters, Leona C.; Brandhorst, J.S.; Hanna, Michael G.

doi:10.1016/0022-4804(81)90180-3

Cited by 21 publications

(6 citation statements)

References 11 publications

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“…The results reported here demonstrate that 16 of 17 animals (94%) were cured of L10 metastases remaining in lymph nodes after limited surgery for stage II disease, whereas the vaccine containing BCG cell walls and mineral oil in emulsified form plus L10X cured 33 of 49 (67%) guinea pigs [7]. Hoover et al [6] used the same t~tmor model to test the efficacy of limited surgery and tumor-specific immunization in the treatment of animals with stage II disease. Their vaccine, containing L10X plus live BCG, cured 35%-55% of the treated aniamls [6].…”

Section: Discussionmentioning

confidence: 77%

“…Their vaccine, containing L10X plus live BCG, cured 35%-55% of the treated aniamls [6]. In addition to the improved efficacy of our vaccine, it has some other advantages over those reported previously [1,6,7,18]. It contained nonliving whole BCG organisms, rather than live BCG [6,18] or BCG cell walls [1,7,18].…”

Section: Discussionmentioning

confidence: 83%

“…In addition to the improved efficacy of our vaccine, it has some other advantages over those reported previously [1,6,7,18]. It contained nonliving whole BCG organisms, rather than live BCG [6,18] or BCG cell walls [1,7,18]. Live BCG cause detrimental side-effects, which do occur occasionally in treated patients.…”

Section: Discussionmentioning

confidence: 88%

“…Hoover et al [6] used the same t~tmor model to test the efficacy of limited surgery and tumor-specific immunization in the treatment of animals with stage II disease. Their vaccine, containing L10X plus live BCG, cured 35%-55% of the treated aniamls [6]. In addition to the improved efficacy of our vaccine, it has some other advantages over those reported previously [1,6,7,18].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A specific vaccine effective against stage I and stage II malignant disease in guinea pigs effect of variations in preparations and storage

Yarkoni

Hunter

Sukumar

1982

Cancer Immunol Immunother

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Guinea pigs, each with an established, syngeneic dermal line 10 tumor and lymph node metastases, were immunized by intradermal injection of a mixture of irradiated line 10 cells and an emulsion containing heat-killed BCG. Immunization eradicated 7- or 10-day-old dermal tumors (about 10 or 12 mm in diameter, respectively) and prevented growth of microscopic lymph node metastases. Fourteen-day-old dermal tumors (about 15 mm in diameter) were not rejected by immunization. Guinea pigs with stage II disease (21-day-old dermal tumors and palpable metastases in the first draining lymph node) were treated by excision of the dermal tumor and the first draining lymph node, and by specific immunization. This treatment eliminated tumor cells remaining in the second draining lymph nodes. The surgical treatment alone was not curative, palpable metastases in the second draining lymph nodes progressed and the animals died (some with visible lung metastases). Emulsions containing killed BCG were good adjuvants even after prolonged storage at 4 degrees C, but lost most of their adjuvant activity after autoclaving or freezing.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A specific vaccine effective against stage I and stage II malignant disease in guinea pigs effect of variations in preparations and storage

Yarkoni

Hunter

Sukumar

1982

Cancer Immunol Immunother

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“…Preclinical models showed that the injection of BCG and tumour cells (OncoVAX®) was able to activate systemic immunity and stop the tumour burden [59]. …”

Section: Focus On Colorectal Cancermentioning

confidence: 99%

Immunotherapy in Gastrointestinal Cancers

Procaccio

Schirripa

Fassan

et al. 2017

BioMed Research International

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Gastrointestinal cancers represent a major public health problem worldwide. Immunotherapeutic strategies are currently under investigation in this setting and preliminary results of ongoing trials adopting checkpoint inhibitors are striking. Indeed, although a poor immunogenicity for GI has been reported, a strong biological rationale supports the development of immunotherapy in this field. The clinical and translational research on immunotherapy for the treatment of GI cancers started firstly with the identification of immune-related mechanisms possibly relevant to GI tumours and secondly with the development of immunotherapy-based agents in clinical trials. In the present review a general overview is firstly provided followed by a focus on major findings on gastric, colorectal, and hepatocellular carcinomas. Finally, pathological and molecular perspectives are provided since many efforts are ongoing in order to identify possible predictive biomarkers and to improve patients' selection. Many issues are still unsolved in this field; however, we strongly believe that immunotherapy might positively affect the natural history of a subgroup of GI cancer patients improving outcome and the overall quality of life.

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Adjuvant immunotherapy treatment of renal carcinoma patients with autologous tumor cells and Bacillus Calmette-Guèrin: Five-year results of a prospective randomized study

Galligioni

Quaia

Merlo³

et al. 1996

Cancer

154

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Therapy of spontaneous metastases with an autologous tumor vaccine in a guinea pig model

Cited by 21 publications

References 11 publications

A specific vaccine effective against stage I and stage II malignant disease in guinea pigs effect of variations in preparations and storage

A specific vaccine effective against stage I and stage II malignant disease in guinea pigs effect of variations in preparations and storage

Immunotherapy in Gastrointestinal Cancers

Adjuvant immunotherapy treatment of renal carcinoma patients with autologous tumor cells and Bacillus Calmette-Guèrin: Five-year results of a prospective randomized study

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