Therapy of rheumatoid arthritis by placenta-eluted gammaglobulins

Clot, J; Sany, J; Bonneau, M.; Cosso, B.; Andary, M

doi:10.1016/0192-0561(82)90239-9

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“…16 derived from placentae by acidic elution [4,5]. This preparation not only showed the highest cytotoxicity titers, but had a marginal IPI factor concentration of 0.08 mg/ml which almost exactly corresponded to that of the B lymphocyte rosetting inhibition test (0.1 mg/ml) as described by Clot et al [7]. Finally, our finding that the only IPI negative preparation was a pepsin-digested product confirms that the Fc portion of immunoglobulins is a prerequisite for their effect [13].…”

Section: Discussionmentioning

confidence: 90%

Immune phagocytosis inhibition by commercial immunoglobulins

Neppert

Clemens

Mueller-Eckhardt

1986

Blut

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Sixteen commercially available immunoglobulins (Ig) and 5 anti-Rho (D) hyperimmune globulins were investigated for immune phagocytosis inhibition (IPI) factors as well as for T, B lymphocytotoxic and monocytotoxic antibodies. All Ig contained IPI factors with lowest inhibitory IgG concentrations ranging from 0.08 to 50 mg/ml. Pepsin-digested Ig was noninhibitory. IPI factors in anti-D preparations were uniformly high (inhibitory IgG concentrations 0.6-2.5 mg/ml). Cytotoxic antibodies against T, B lymphocytes and monocytes were found in 2,2 and 7 products, respectively. Since we have recently shown that IPI is caused by antibodies against major histocompatibility complex antigens, most likely HLA, the hypothesis is put forward that IPI factors in Ig are HLA-related, cytotoxic as well as noncytotoxic antibodies which act via Fc receptor blockade of human monocytes.

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Section: Discussionmentioning

confidence: 90%