Therapy of Older People for Myocardial Infarction

Aronow, Wilbert S.; Tresch, Donald D.

doi:10.1111/j.1532-5415.1998.tb06658.x

Cited by 40 publications

(1 citation statement)

References 76 publications

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“…Asymptomatic myocardial infarction (MI) is associated with a high mortality rate, particularly in aging and diabetic populations [1,2], where defects in the transient receptor potential vanilloid (TRPV1)-positive sensory nerve function are known [3,4]. The TRPV1 subtype is a ligand-gated nonselective cation channel, primarily expressed in sensory nerves innervating cardiovascular tissues, including the heart and blood vessels [5,6].…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction

et al. 2016

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Objective: A high mortality rate occurs with silent myocardial infarction (MI), particularlyin aging and diabetic populations due to defects in the transient receptor potential vanilloid (TRPV1)-positive sensory nerve function. We have previously shown that TRPV1 deficiency markedly enhances post-MI inflammation and remodeling. However, the mechanisms remain unknown. The objective of this study was to clarify whether calcitonin gene-related peptide (CGRP) release was associated with the protective role of TRPV1 against postmyocardial inflammation and apoptosis. Methods: TRPV1 gene knockout (TRPV1KO) and wild-type (WT) mice were subjected to left anterior descending ligation or sham operation. The concentration of CGRP in the myocardium was measured at 30 min, 1, 6 and 24 h post-MI. Mice received saline vehicle, CGRP or the CGRP antagonist CGRP_8-37 before ligation. Inflammation was evaluated by ELISA assay and histological staining. Apoptosis was assessed by Western blot and TUNEL assay. Results: Post-MI, both TRPV1KO and WT mice displayed elevated CGRP levels in myocardium when compared to sham controls. However, the levels of CGRP were significantly lower in TRPV1KO mice than in WT mice at 30 min after MI. Exogenous CGRP downregulated the levels of tumor necrosis factor-α and interleukin-6 expression in TRPV1KO mice post-MI. Moreover, exogenous CGRP decreased the neutrophil infiltration in TRPV1KO mice, whereas inhibition of CGRP by CGRP_8-37 increased the neutrophil infiltration in WT mice. Western blotting data indicated that CGRP attenuated caspase-3 and caspase-9 expression, and enhanced Bcl-2 expression in TRPV1KO mice post-MI. CGRP_8-37 upregulated caspase-3 and caspase-9 expression and downregulated Bcl-2 expression in WT mice. Conclusion: Our data suggest a protective role of TRPV1 activation against inflammation and apoptosis in mice post-MI, possibly through CGRP release. These findings elucidate a neurogenic mechanism in mice post-MI, which may participate in sensory neurotransmitter-mediated protection in TRPV1 activation.

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Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction

et al. 2016

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A randomized controlled trial to reduce delay in older adults seeking help for symptoms of acute myocardial infarction

Tullmann

Haugh

Dracup

et al. 2007

Research in Nursing & Health

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Older adults with symptoms of acute myocardial infarction (AMI) have longer pre-treatment delay times than their younger counterparts. A 2-group, randomized controlled sample consisted of 115 adults, 65 years of age or older with a self-reported history of coronary artery disease. A pre-test was given to all participants followed by a structured education and counseling intervention to those in the experimental group. Data were re-collected at 3 months. There was a statistically significant increase in knowledge, beliefs, and perceived control without an increase in anxiety in the intervention group. There was no significant difference in attitudes. Older adults at risk for AMI should be targeted for individualized education and counseling in clinics, physician offices, and community centers.

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Heart Disease in the Elderly

Rich¹

Essential Cardiology

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Therapy of Older People for Myocardial Infarction

Cited by 40 publications

References 76 publications

Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction

Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction

A randomized controlled trial to reduce delay in older adults seeking help for symptoms of acute myocardial infarction

Heart Disease in the Elderly

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