Therapy of human rabies

“…Kuluçka süresi genellikle 4 ila 6 haftadır, ancak bir yıldan uzun süreler bildirilmiştir. Baş ve yüze şiddetli ısırıkları olan hastalarda 2 hafta veya daha az inkübasyon süreleri gözlenmiştir (9). Hastamızda da 3 ay önce köpek ısırması hikayesi mevcuttu.…”

Section: Discussionunclassified

“…Şüpheli hayvan teması mutlaka sorgulanmalıdır. Kesin tanı ise bizim olgumuzda da olduğu gibi virüsün izolasyonu ile mümkündür (9). Hastamızın ense saç folikülünden alınan örneğinde RT-PCR ile kuduz virüsü tespit edilmiştir Bizim olgumuzda olduğu gibi hastalarda nörolojik bulgular geliştiğinde prognoz oldukça kötüdür ve genellikle ölümle sonuçlanır.…”

Section: Discussionunclassified

A case of rabies encephalitis after 3 months due to dog bite in Azerbaijan

KILINÇ¹,

Atik²,

Atasoy³

et al. 2019

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“…This zoonosis has the highest case fatality of any infectious disease, with death typically occurring within 14 days of onset of clinical signs. Since the 1970s, survival has been well documented in only around 30 of the estimated 3 million human cases that have occurred in that time ( 3 – 5 ). Of these survivors, most suffered severe neurological sequelae ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

A One Medicine Mission for an Effective Rabies Therapy

et al. 2022

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Despite the disease's long history, little progress has been made toward a treatment for rabies. The prognosis for patient recovery remains dire. For any prospect of survival, patients require aggressive critical care, which physicians in rabies endemic areas may be reluctant or unable to provide given the cost, clinical expertise required, and uncertain outcome. Systematic clinical research into combination therapies is further hampered by sporadic occurrence of cases. In this Perspective, we examine the case for a One Medicine approach to accelerate development of an effective therapy for rabies through the veterinary care and investigational treatment of naturally infected dogs in appropriate circumstances. We review the pathogenesis of rabies virus in humans and dogs, including recent advances in our understanding of the molecular basis for the severe neurological dysfunction. We propose that four categories of disease process need to be managed in patients: viral propagation, neuronal degeneration, inflammation and systemic compromise. Compassionate critical care and investigational treatment of naturally infected dogs receiving supportive therapy that mimics the human clinical scenario could increase opportunities to study combination therapies that address these processes, and to identify biomarkers for prognosis and therapeutic response. We discuss the safety and ethics of this approach, and introduce the Canine Rabies Treatment Initiative, a non-profit organization with the mission to apply a One Medicine approach to the investigation of diagnostic, prognostic, and therapeutic options for rabies in naturally infected dogs, to accelerate transformation of rabies into a treatable disease for all patients.

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Therapy of human rabies

Cited by 11 publications

References 76 publications

A Case of Rabies Encephalitis after 3 Months Due to Dog Bite in Azerbaijan

A Case of Rabies Encephalitis after 3 Months Due to Dog Bite in Azerbaijan

A case of rabies encephalitis after 3 months due to dog bite in Azerbaijan

A One Medicine Mission for an Effective Rabies Therapy

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