Therapy of asthenoneurotic syndrome in patients with focal muscular dystonia

Суворова, В. А.; Антипенко, Е. А.

doi:10.17116/jnevro20181183156-58

Z. nevrol. psikhiatr. im. S.S. Korsakova

2018

DOI: 10.17116/jnevro20181183156-58

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Therapy of asthenoneurotic syndrome in patients with focal muscular dystonia

В. А. Суворова

Е. А. Антипенко

Abstract: Asthenic syndrome and anxiety disorder are independent non-motor manifestations of focal muscular dystonia. Adaptol has a positive effect, significantly reducing anxiety and asthenia in patients with focal muscular dystonia.

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“…However, this cannot fundamentally solve the problem of neuron degeneration and loss, whereas using new neurons to replace missing ones can fundamentally solve the problem. Therefore, cell replacement therapy is universally considered an ideal method [5][6][7][8][9] .…”

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confidence: 99%

The Impact of microRNA-29a-3p on the Neural Stem Cell Differentiation Process into Neurons

Shi,

Zhou,

Dai

et al. 2023

IJPS

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Shi et al.: microRNA-29a-3p Impact on the Neural Stem Cell DifferentiationTo explore how microRNA-29a-3p influences the differentiation of neural stem cells into neurons and to identify any potential mechanisms involved. The program TargetScan, available online was utilized to examine and make predictions about the microRNA-29a-3p located upstream that regulate doublecortin X messenger ribonucleic acid. Ultimately, microRNA-29a-3p was preferred as the main central point of the investigation. The targeting of doublecortin X gene by microRNA-29a-3p was validated by employing a dual-luciferase reporter gene system. Before subjecting to adherent differentiation, the neural stem cells were transfected with microRNA-29a-3p inhibitor, microRNA-29a-3p mimic and normal control. MicroRNA and doublecortin X messenger ribonucleic acid levels were measured through quantitative reverse transcriptionpolymerase chain reaction and doublecortin X protein levels were determined through Western blot assays. The differentiation of neuronal precursor cells was detected by doublecortin X immunofluorescence. Neuronal differentiation was detected by microtubule-associated protein 2 immunofluorescence. According to the dual-luciferase reporter gene system, miR-29a-3p targeted the doublecortin X gene; microRNA-29a-3p significantly decreased in differentiated cells for 3 d was observed, along with a significant reduction in levels of doublecortin X protein and messenger ribonucleic acid. On the other hand, a significant raise in microRNA-29a-3p in differentiated cells of microRNA-29a-3p mimic group for a period of 3 d was noticed with a significant drop in protein levels, doublecortin X messenger ribonucleic acid and doublecortin X immunofluorescence-positive neuronal precursor cells. From the microtubule-associated protein 2 immunofluorescence, it was confirmed that microRNA-29a-3p inhibitor group significantly elevated the total number of neurons, while microRNA-29a-3p mimic reduced the neurons on 7 d. Therefore, low expression of microRNA-29a-3p promote differentiation of neural stem cells into neurons via targeting doublecortin X.

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mentioning

confidence: 99%

The Impact of microRNA-29a-3p on the Neural Stem Cell Differentiation Process into Neurons

Shi,

Zhou,

Dai

et al. 2023

IJPS

View full text Add to dashboard Cite

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Cervical dystonia: non-motor aspects

Дружинина

Жукова

Шперлинг³

et al. 2020

RJTAO

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Цервикальная дистония (ЦД) проявляется насильственными, часто болезненными движениями мышц шеи с формированием патологической позы головы и/или шеи. Прогрессирование заболевания приводит к инвалидизации больных. Для клинической картины заболевания характерно сочетание двигательных и немоторных нарушений. Цель исследования -анализ особенностей немоторных проявлений (боль, астения, тревога, депрессия, нарушения сна) и качества жизни (КЖ) у пациентов с ЦД.

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Non-motor conditions in patients with cervical dystonia

Дружинина

Жукова

Шперлинг³

2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Therapy of asthenoneurotic syndrome in patients with focal muscular dystonia

Abstract: Asthenic syndrome and anxiety disorder are independent non-motor manifestations of focal muscular dystonia. Adaptol has a positive effect, significantly reducing anxiety and asthenia in patients with focal muscular dystonia.

Cited by 3 publications

References 6 publications

The Impact of microRNA-29a-3p on the Neural Stem Cell Differentiation Process into Neurons

The Impact of microRNA-29a-3p on the Neural Stem Cell Differentiation Process into Neurons

Cervical dystonia: non-motor aspects

Non-motor conditions in patients with cervical dystonia

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