Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients

Klimek, Ludger; Casper, Ingrid; Bergmann, Karl‐Christian; Biedermann, Tilo; Bousquet, Jean; Hellings, Peter; Jung, Kirsten; Mösges, Ralph; Schlenter, Wolfgang; Gröger, Moritz; Ring, Johannes; Chaker, Adam; Pfaar, Oliver; Wehrmann, Wolfgang; Zuberbier, Torsten; Becker, Sven

doi:10.1007/s40629-020-00133-7

Cited by 7 publications

(4 citation statements)

References 70 publications

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“…Microteaching is a kind of digital teaching resource with micro-video as the core, which has the characteristics of being short and concise, targeted, flexible, convenient, and suitable for the learning needs of different interns [1][2][3] . The PBL teaching mode, on the other hand, is a problem-oriented teaching method, which emphasizes that students take the initiative to learn and think during the process of solving practical problems, and cultivates their comprehensive quality and innovation ability [4][5][6] . Under the current medical situation, combining microteaching with PBL teaching mode and applying it to the teaching of clinical nursing interns in otolaryngology department has certain practical significance and application value.…”

Section: Introductionmentioning

confidence: 99%

Application of Microteaching Combined with Problem-Based Learning (PBL) Teaching Model in Teaching Clinical Nursing Interns in Otorhinolaryngology Department

Yang,

Yao,

Jiang

et al. 2023

JCER

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Objective: To explore the application effect of microteaching combined with problem-based learning (PBL) teaching mode in teaching clinical nursing interns in otorhinolaryngology department. Methods: A total of 72 nursing students who interned in our hospital from June 2022 to February 2023 were selected, and all of them were comprehensively trained in basic theoretical knowledge as well as practical skills before the beginning of their learning tasks. The students were randomly divided into the control group and the experimental group, with 36 students in each group. The control group was taught using the traditional clinical nursing teaching mode, and the experimental group was taught using microteaching combined with the PBL teaching mode, subsequently comparing the differences between the two groups of interns in the degree of mastery of theoretical knowledge, hands-on skills, teamwork ability, patient satisfaction, and other aspects. Results: In terms of mastery of theoretical knowledge, the interns in the experimental group (97.22%) were significantly better than that of the control group (75.00%) (P < 0.05); the interns in the experimental group had significantly better practical skills (77.78%) than that of the control group (55.56%) (P < 0.05); the interns in the experimental group had significantly better teamwork ability than the control group (P < 0.05); through the questionnaire survey, it was found that students’ satisfaction with teaching in the experimental group (97.22%) was also significantly higher than that in the control group (75.00%) (P < 0.05). Conclusion: The application of microteaching combined with PBL teaching mode in the teaching of clinical nursing interns in otorhinolaryngology department achieved significant results. It can not only improve the professional knowledge and application ability of nursing students, but also cultivate their independent thinking, problem-solving skill, as well as teamwork ability. It can also improve the teaching quality and patient satisfaction, and contribute positively to the development of medical education.

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Section: Introductionmentioning

confidence: 99%

Application of Microteaching Combined with Problem-Based Learning (PBL) Teaching Model in Teaching Clinical Nursing Interns in Otorhinolaryngology Department

Yang,

Yao,

Jiang

et al. 2023

JCER

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“…Moderate to severe AR patients often do not feel sufficiently treated with the INCS monotherapy and resort to combinations of different drugs with different mechanisms of action. 19 Finding the right combination can help reduce symptoms and improve the patient's quality of life. Montelukast is a cysteinyl leukotriene receptor antagonist that is prescribed both in asthma and AR alone or together with other drugs and one of the first step drugs of ARIA guidelines and has 5hours onset of action.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Montelukast and Azelastine add on Therapy in Moderate to Severe Allergic Rhinitis Treatment: A Double-Blind Randomized Clinical Trial

Esmaeilzadeh

Far

Nabavizadeh

et al. 2022

Am J Rhinol�Allergy

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Background Allergic Rhinitis (AR) is a prevalent chronic inflammatory nasal condition with significant negative effects on the patients’ quality of life. This study aimed to investigate the efficacy of Montelukast and intranasal antihistamine in combination with intranasal corticosteroid (INCS) in moderate to severe allergic rhinitis on the patients’ quality of life and AR control. Method This double-blind randomized clinical trial study was carried out on 66 moderate to severe AR patients referred to Namazi Hospital, Shiraz, Iran from 2020 to 2021, who were randomly divided into 3 groups. Group one received Montelukast add-on therapy and Budesonide nasal spray. The second group received intranasal antihistamine (Azelastine) add-on therapy and Budesonide nasal spray and the third group as the control group received intranasal Budesonide spray with a placebo tablet. To measure the impact of each medication on the patient's quality of life and AR control, we employed the Sino-Nasal Outcome Test-22 questionnaire (SNOT 22). We evaluated the symptoms and compared them at baseline, one and three months after the start of treatments. Spirometry was performed to investigate the possibility of co-morbid asthma at baseline and end of the study. Results The patients’ mean age was 30.13 ± 12.7 years. Most patients experienced perennial AR (65.2%). Reduction of mean scores SNOT22 was statistically different between groups (P-value < 0.001). Three months after treatment, the mean decrease of SNOT-22 in the Azelastine group was statistically significant compared to both Montelukast (P-value < 0.001) and control groups (P-value < 0.001). No significant difference was observed between the Montelukast and control groups (P-value = 0.142). 23 of 66 patients were diagnosed with asthma and asthma treatment was initiated. The amount of FEV1 change after AR treatment was not statistically significant between the groups in asthmatic patients (P-value = 0.351). Conclusion Based on our findings, we recommend Azelastine in conjunction with an intranasal corticosteroid for the treatment of moderate to severe allergic rhinitis. In moderate to severe AR or even asthma management, Montelukast has no greater impact than INCS.

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“…einen schwereren Verlauf der Erkrankung hervorrufen könnten und hierdurch zahlreiche Patienten mit AR, CRS und Asthma massiv verunsichert wurden, wiesen Positionspapiere der deutschen und europäischen Gesellschaften sehr frühzeitig in der Pandemie auf die Notwendigkeit einer Fortführung der Therapie mit topischen GKS hin [ 1 , 2 ]. Demnach sind topische GKS als nasale (nGKS) und inhalative (ICS) Form effektiv in der Behandlung von Schleimhautentzündungen der oberen und unteren Atemwege und stellen die Standardtherapie dieser Erkrankungen dar [ 8 – 11 ].…”

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Stellungnahme zum Einsatz von topisch-inhalativem Budesonid bei COVID-19-Infektion

Buhl

Becker

Klimek

et al. 2021

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Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients

Abstract: Ageing and chronic diseases epidemiological and public health approaches, INSERM U

Cited by 7 publications

References 70 publications

Application of Microteaching Combined with Problem-Based Learning (PBL) Teaching Model in Teaching Clinical Nursing Interns in Otorhinolaryngology Department

Application of Microteaching Combined with Problem-Based Learning (PBL) Teaching Model in Teaching Clinical Nursing Interns in Otorhinolaryngology Department

A Comparative Study of Montelukast and Azelastine add on Therapy in Moderate to Severe Allergic Rhinitis Treatment: A Double-Blind Randomized Clinical Trial

Stellungnahme zum Einsatz von topisch-inhalativem Budesonid bei COVID-19-Infektion

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