Therapy for naming deficits in two variants of primary progressive aphasia

Newhart, Melissa; Davis, Cameron; Kannan, Vijay C.; Heidler‐Gary, Jennifer; Cloutman, Lauren; Hillis, Argye E.

doi:10.1080/02687030802661762

Cited by 67 publications

(72 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although PPA is a progressive condition, intervention can be helpful in at least temporarily improving production of trained sets of words in both speech [47] and writing [48], which in turn may improve the individual's quality of life, sense of accomplishment and perhaps contribute to their maintenance of language functions over time. Other reasonable goals of treatment might be to reduce the rate of language decline and to provide effective alternative communication strategies.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Dysgraphia in Primary Progressive Aphasia Compared to Post-Stroke Aphasia

Faria

Crinion

Tsapkini

et al. 2013

Behavioural Neurology

Self Cite

View full text Add to dashboard Cite

Abstract. We report patterns of dysgraphia in participants with primary progressive aphasia that can be explained by assuming disruption of one or more cognitive processes or representations in the complex process of spelling. These patterns are compared to those described in participants with focal lesions (stroke). Using structural imaging techniques, we found that damage to the left extrasylvian regions, including the uncinate, inferior fronto-occipital fasciculus, and sagittal stratum (including geniculostriate pathway and inferior longitudinal fasciculus), as well as other deep white and grey matter structures, was significantly associated with impairments in access to orthographic word forms and semantics (with reliance on phonology-to-orthography to produce a plausible spelling in the spelling to dictation task). These results contribute not only to our understanding of the patterns of dysgraphia following acquired brain damage but also the neural substrates underlying spelling.

show abstract

Section: Discussionmentioning

confidence: 99%

Patterns of Dysgraphia in Primary Progressive Aphasia Compared to Post-Stroke Aphasia

Faria

Crinion

Tsapkini

et al. 2013

Behavioural Neurology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Almost all previous studies showed that participants improved on therapy items immediately post-treatment, as reviewed by Croot, Nickels, Laurence, and Manning (2009). The available data indicate that (i) relearning is possible, (ii) therapy effects are generally restricted to treated items, and (iii) effects decline substantially over time without ongoing practice (Bier et al, 2009;Frattali, 2004;Graham, Patterson, Pratt, & Hodges, 1999, 2001Heredia, Sage, Lambon Ralph, & Berthier, 2009;Jokel, Rochon, & Leonard, 2002Newhart et al, 2009;Snowden & Neary, 2002). The degree of success of anomia treatment in SD and the ability to maintain relearned words seem to rely on the severity of the semantic deficit Henry, Beeson, & Rapcsak, 2008a, 2008bSnowden & Neary, 2002).…”

mentioning

confidence: 93%

Model-oriented naming therapy in semantic dementia: A single-case fMRI study

et al. 2010

View full text Add to dashboard Cite

Background: Studies on anomia treatment in semantic dementia demonstrate that re-learning is possible, but maintenance and generalisation of improvements are limited. Changes in cortical activation associated with anomia treatment have already been demonstrated in aphasic patients after stroke. Recovery of brain functions under the impact of deficit-specific treatment in semantic dementia has not been explored yet. Nevertheless, recent activation studies using language tasks in patients with neurodegenerative diseases report altered activation patterns, involving diverse brain regions ipsi-or contralateral to the primarily affected left hemisphere. Aims: The purpose of the present study was to investigate if phonological and semantic cueing hierarchies established for naming therapy in aphasia were also effective in a patient with semantic dementia. Moreover, we aimed to examine changes of brain activity associated with anomia treatment. Methods & Procedures:One individual with semantic dementia participated in the present study. Over a period of 4 weeks the participant received an intensive model-oriented treatment with phonological and semantic cueing hierarchies. Two pre-tests and two post-tests (one immediately after training and one 2 months later) were administered. The second pre-test and both follow-ups were registered inside the scanner. Outcomes & Results: Behaviourally, both treatments resulted in specific training effects, which subsequently decreased over time. Concerning functional magnetic resonance imaging data, improved naming following therapy was mirrored by changes in cortical activity, predominantly located in right superior and inferior temporal gyrus. Conclusions: Cueing hierarchies were successful, resulting in specific and immediate treatment effects, corroborating previous treatment studies in semantic dementia. Treatment-induced changes in cortical activity were mainly concentrated in right temporal cortex. Since right-sided modulation of cortical activity was associated with

show abstract

“…Des thé rapies de ré apprentissage sont é galement proposé es à l'aide de tâ ches sé mantiques [120], de dé nomination d'images de caté gories diffé rentes avec indices hié rarchisé s [121], de dé nomination et de maniement sé mantique caté goriel [122], d'exercices de compré hension et de production orale et é crite [123] et de straté gie d'auto-indiç age pour faciliter l'accè s lexical [124]. Ces thé rapies permettent une gé né ralisation à d'autres items non traité s au cours des sé ances et un maintien des acquis allant de 3 semaines, pour les gé né ralisations, à 6 mois pour les items traité s. Un essai avec des tâ ches d'é pellation se ré vè le par contre moins concluant sur la gé né ralisation et le maintien de l'effet [125].…”

Section: Traitementunclassified