Therapy and Prognosis of Carcinoma of the Renal Pelvis

Vahlensieck, W; Sommerkamp, H.

doi:10.1159/000471593

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…However, unlike the majority of urothelial neoplasms of the bladder which are noninvasive at presentation, 37 many studies of renal pelvic tumors have shown that most patients present with invasion, with only a 3.5-34% incidence of noninvasive disease. 14,15,19,[22][23][24]38,39 In our analysis and others, 20 a significantly greater number of cases demonstrated low-stage disease than highstage disease (69% rpT1 disease vs 31% ZpT2 disease), which closely approximates the 70% of bladder tumors which are 'superficial' (pTa, pTIS, pT1) at presentation. 36,37 In two more recent series of renal pelvic tumors, Gomez et al 38 and Olgac et al 39 also reported that a slightly greater number of tumors were low stage (rpT1) than high stage.…”

Section: Discussionsupporting

confidence: 70%

“…The prognosis of patients with these tumors has repeatedly been shown to depend on the tumor stage and grade. [9][10][11][13][14][15][17][18][19][21][22][23][24] At nephrectomy, our study group was divided nearly equally into those with noninvasive disease and those with an invasive component ( Table 2). Nielsen and Ostri 21 in their study of primary tumors of the renal pelvis had a slightly greater percentage (56%) of noninvasive tumors.…”

Section: Discussionmentioning

confidence: 99%

“…5 In certain regions of the world, and in patients with certain tubulointerstitial nephritides, the incidence of urothelial neoplasms of the renal pelvis and ureter is quite high, with renal pelvic carcinoma accounting for as much as 68% of renal tumors in some series. 4,6 As a result of the general scarcity of these tumors, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] coupled with the even lower incidence of ureteral urothelial tumors (1% of urothelial neoplasms), 2 a large proportion of published reports incorporate tumors at both sites into single studies. There have been few analyses of renal pelvic urothelial neoplasms recently in the pathology literature.…”

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Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

et al. 2005

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The classification of urothelial neoplasms of the kidney traditionally has been similar to that of urinary bladder tumors. Several years ago, the classification of papillary urothelial neoplasms was revised. The current study focuses on the application of the 1998 World Health Organization (WHO)/International Society of Urological Pathology classification system to 102 renal pelvic urothelial neoplasms and compares it to the 1973 WHO classification scheme. In this study, all tumors were classified as urothelial carcinomas, and the majority (85%) were papillary. Most patients with papillary tumors presented with 'superficial' disease (rpT1). With the 1998 system, most papillary carcinomas were high grade, and were more often invasive as compared to low-grade tumors. Only 34% were low-grade papillary tumors and, of these, most (93%) were noninvasive. With the 1973 system, most papillary tumors were grade 2 or 3, with invasion more common in grade 3 tumors. By 1973 criteria, grade 2 tumors were a heterogeneous group; with 1998 criteria, nearly one-half were high grade and the other half low grade. The grade of papillary urothelial carcinomas with both the 1973 and 1998 grading methods was associated with stage (P ¼ 0.001). Our study reveals that papillomas and papillary urothelial neoplasms of low malignant potential are uncommon tumors in the kidney. Renal pelvic papillary urothelial neoplasms are most often carcinomas and are more commonly high grade than low grade. Although both the 1973 and 1998 systems showed a significant association with tumor stage, grade 2 papillary carcinomas are a heterogeneous group by 1973 criteria. The 1998 system provides useful information in that it more clearly defines a papillary tumor's grade and selects for a group of tumors, namely low-grade papillary urothelial carcinomas, for which a low likelihood of invasion can be predicted.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

et al. 2005

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“…Die klassischen Hauptsymptome, mit denen sich die Patientinnen vorstellten, waren Hämaturie oder Dysurie und Flankenschmerz gefolgt von einer tastbaren abdominellen Raumverände-rung [3,30,34]. In früheren Literaturübersichten [24,36] stellte die tastbare Raumveränderung das bei weitem am häufigsten berichtete Symptom dar.…”

Section: Introductionunclassified

“…Fortwäh-rende Verbesserungen in der bildgebenden Diagnostik führten dazu, daû die Diagnosestellung heute in nahezu 60 % der Fälle sonographisch erfolgt. CT-Untersuchungen erreichen Nachweisgrenzen von knapp 90 % [34]. Der standardisierte diagnostische Algorithmus beim Verdacht auf eine urotheliale Neoplasie von Sonographie, Ausscheidungsurographie mit Leerschicht-und Spätaufnahmen und ggf.…”

Section: Introductionunclassified

Spontanruptur einer Niere post partum aufgrund eines urothelialen Karzinoms

et al. 1999

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The case of a spontaneous kidney rupture due to an urothelial carcinoma one week after delivery is presented. Diagnosis was made during operation. In comparison to the carcinoma, which is diagnosed and treated in time, the prognosis is poor. The patient deserved continuous gynecological follow-up and showed the classic symptoms of an urothelial carcinoma for six months. In spite of regular sonographic controls during pregnancy the tumor was not diagnosed. Diagnosis and management of renal carcinomas during pregnancy are discussed.

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Beta-human chorionic gonadotropin-positive extragonadal germ cell neoplasia of the renal pelvis

Vahlensieck¹,

Riede²,

Ihling³

et al. 1991

Cancer

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A 56-year-old woman showed renal obstruction on the right side. Further examinations revealed a tumor of the renal pelvis. Nephroureterectomy on the right side was done. This extragonadal germ cell neoplasia had an immunohistochemically detected beta-human chorionic gonadotropin (beta-hCG) expression. There were no other primary tumors or metastases. Although there were normal values after the operation, during the postoperative follow-up, the serum beta-hCG temporarily reached 2400 IU/l and then dropped to normal without detection of metastases. No further therapy was given. The patient was alive and well 1 year and 10 months after surgery. To the authors' knowledge, this is the first extragonadal germ cell neoplasia of the renal pelvis with secretion of beta-hCG to the serum.

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Therapy and Prognosis of Carcinoma of the Renal Pelvis

Cited by 9 publications

References 12 publications

Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney

Spontanruptur einer Niere post partum aufgrund eines urothelialen Karzinoms

Beta-human chorionic gonadotropin-positive extragonadal germ cell neoplasia of the renal pelvis

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