Therapies with potential toxicity of neuro-ophthalmic interest

Iuorno, Joseph D.; Kolostyak, Kevin P.; Mejico, Luis J.

doi:10.1097/00055735-200312000-00004

Cited by 2 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A clinical trial with lenercept for treatment of relapsingremitting MS showed an earlier onset and increased number of clinical exacerbations in those treated with lenercept versus placebo [4]. There have also been a number of case reports of infliximab-associated demyelinating disease, including several instances of new onset, unilateral retrobulbar optic neuritis supported by radiographic evidence [5][6][7]. Treatment with steroids was instituted in these latter cases with rapid resolution of the event.…”

Section: Discussionmentioning

confidence: 99%

Adalimumab-associated optic neuritis

Chung¹,

Stavern

Frohman³

et al. 2006

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Adalimumab-associated optic neuritis

Chung¹,

Stavern

Frohman³

et al. 2006

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Neuroanatomy and Sampling of Central Projections for the Visual System in Mammals Used in Toxicity Testing

Muthuswamy

Pardo

Rao³

et al. 2020

Toxicol Pathol

View full text Add to dashboard Cite

Visual system toxicity may manifest anywhere in the visual system, from the eye proper to the visual brain. Therefore, effective screening for visual system toxicity must evaluate not only ocular structures (ie, eye and optic nerve) but also multiple key brain regions involved in vision (eg, optic tract, subcortical relay nuclei, and primary and secondary visual cortices). Despite a generally comparable pattern across species, the neuroanatomic organization and function of the visual brain in rodents and rabbits exhibit appreciable differences relative to nonrodents. Currently recognized sampling practices for general toxicity studies in animals, which are based on easily discerned external neuroanatomic landmarks and guided by extant stereotaxic brain atlases, typically will permit histopathologic evaluation of many brain centers involved in visual sensation (eg, optic chiasm, optic tract, dorsal lateral geniculate nucleus, primary and secondary visual cortices) and often some subcortical brain nuclei involved in light-modulated nonvisual activities needed for visual attention and orientation (eg, rostral colliculus in quadrupeds, termed the superior colliculus in bipeds; several cranial nerve nuclei). Pathologic findings induced by toxicants in the visual brain centers are similar to those that are produced in other brain regions.

show abstract

Therapies with potential toxicity of neuro-ophthalmic interest

Abstract: Appropriate management requires prompt recognition of these associations. Practitioners should be familiar with these neuro-ophthalmic manifestations because they may present in the course of daily practice.

Cited by 2 publications

References 36 publications

Adalimumab-associated optic neuritis

Adalimumab-associated optic neuritis

Neuroanatomy and Sampling of Central Projections for the Visual System in Mammals Used in Toxicity Testing

Contact Info

Product

Resources

About