Therapieinduzierte Effekte am Normalgewebe

Kaick, G. van; Delorme, Stefan

doi:10.1007/s00117-008-1729-3

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Anticancer medications (chemotherapy, CT) may be prescribed, as well as radiation therapy (RT). CT- or RT is cytotoxic, not only slowing down or killing rapidly dividing cells and producing many different types of DNA damage [93], but detrimentally leading to damage of normal tissue, especially of fast-growing healthy cells, including neural progenitor cells (NPCs), and also red and white blood cells [94, 95]. Recent reports show that CT results in cognitive side effects in extracranial cancer (i.e., breast cancer, prostate, etc.)…”

Section: Cognitive Side Effects Of Clinic Therapies For Aberrant Cmentioning

confidence: 99%

Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

Liu

Ander

2012

The Scientific World Journal

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Since publishing our earlier report describing a strategy for the treatment of central nervous system (CNS) diseases by inhibiting the cell cycle and without disrupting neurogenesis (Liu et al. 2010), we now update and extend this strategy to applications in the treatment of cancers as well. Here, we put forth the concept of “aberrant cell cycle diseases” to include both cancer and CNS diseases, the two unrelated disease types on the surface, by focusing on a common mechanism in each aberrant cell cycle reentry. In this paper, we also summarize the pharmacological approaches that interfere with classical cell cycle molecules and mitogenic pathways to block the cell cycle of tumor cells (in treatment of cancer) as well as to block the cell cycle of neurons (in treatment of CNS diseases). Since cell cycle inhibition can also block proliferation of neural progenitor cells (NPCs) and thus impair brain neurogenesis leading to cognitive deficits, we propose that future strategies aimed at cell cycle inhibition in treatment of aberrant cell cycle diseases (i.e., cancers or CNS diseases) should be designed with consideration of the important side effects on normal neurogenesis and cognition.

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Section: Cognitive Side Effects Of Clinic Therapies For Aberrant Cmentioning

confidence: 99%

Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

Liu

Ander

2012

The Scientific World Journal

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“…Osteonecrosis of the mandible constitutes a serious complication following radiation treatment of head/neck tumors [1], chemotherapy for malignant diseases and treatment with bisphosphonates [2, 3]. Independent of its cause, osteonecrosis is defined as non-vital bone tissue resulting from disrupted intraosseous blood supply.…”

Section: Introductionmentioning

confidence: 99%

Etiology and treatment of osteonecrosis of the mandible

Bast

Gross

Hecht

et al. 2013

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Aim of the studyPost-radiogenic osteonecrosis of the mandible is a serious complication in patients with combined treated head/neck tumors. Osteonecrosis of the mandible can also occur following administration of bisphosphonates. In the present article we would like to present our experiences over the last five years in treating both bisphosphonate-associated osteonecrosis and osteoradionecrosis.Material and methodsOf the patients treated in our hospital for bone necrosis of the mandible between January 2005 and June 2010, 16 were diagnosed with infected osteoradionecrosis and 10 with bisphosphonate-associated osteonecrosis. The patients with osteoradionecrosis were administered the classic osteomyelitis treatment. The same procedure was carried out on 5 of the 10 patients with bisphosphonate-associated osteonecrosis; the remaining 5 were treated conservatively due to advanced bone infection. The bone biopsies and specimens of both entities yielded by the surgical interventions were examined histologically after decalcification.ResultsOf the 16 patients treated for infected osteoradionecrosis, 7 recovered after decortication and long-term antibiosis. In 7 cases consolidation did not occur until after osseous continuity resection. In 2 cases the progress of the intraosseous infection could not be stopped with treatment.A typical first symptom of bisphosphonate-associated osteonecrosis was an alveolus that would not heal after a tooth extraction. In 50% of patients with bisphosphonate-associated osteonecrosis recovery was successful with a combination of surgery and long-term antibiosis. In the other patients with advanced bisphosphonate-associated osteonecrosis no definitive cure for the infection of the necrotic bone was possible.ConclusionIn terms of treatment, osteoradionecrosis proves complex, yet easier to treat than bisphosphonate-associated osteonecrosis. The removal of the infected bone tissue is often necessary, but it does not always lead to recovery. Therefore it can be concluded that prevention of intraosseous infection by consistent pretherapeutic dental hygiene is especially important.

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Bone Marrow: Chemotherapy

Jobke

Bloem

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Therapieinduzierte Effekte am Normalgewebe

Cited by 7 publications

References 15 publications

Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

Etiology and treatment of osteonecrosis of the mandible

Bone Marrow: Chemotherapy

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