Therapie der akuten Pankreatitis - Gemeinsame Leitlinien -

Rünzi, Michael; Layer, Peter; Büchler, Markus W.; Beger, H. G.; C, Ell; Fölsch, Ulrich R.; Goebell, H.; Hopt, Ulrich T.; Lankisch, P. G.; Schmidt, WE; Schmiegel, W.; Schölmerich, J.

doi:10.1055/s-2000-7447

Cited by 55 publications

(44 citation statements)

References 17 publications

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“…Pentazocine was administered 30 mg every 6 h intravenously in group B (n = 50) [4, 5]. Additional pentazocine was administered intravenously on demand in both groups and the request of pentazocine was recorded.…”

Section: Methodsmentioning

confidence: 99%

“…The drugs, tested in this study are recommended in several articles [3, 4, 5, 20]. Pentazocine belongs to the group of opioid agonists-antagonists.…”

Section: Discussionmentioning

confidence: 99%

“…Recently the use of procaine as treatment option for pain relief in AP was recommended by the German consensus conferences on management of acute and chronic pancreatitis [3, 4, 5]. The rationale for the use of procaine is its local analgesic effect and its inhibitory effect on phospholipase A 2 catalytic activity, which is a critical enzyme in the pathogenesis of AP [11, 12].…”

Section: Introductionmentioning

confidence: 99%

“…Effective pain control in AP is part of the basic supportive therapy (volume replacement, rehydration). There are several treatment options recommended for pain control in AP [1, 2, 3, 4, 5, 6], but only a few clinical trials have addressed these options to be either effective or not for pain relief in patients with AP [7, 8, 9, 10]. …”

Section: Introductionmentioning

confidence: 99%

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Procaine Hydrochloride Fails to Relieve Pain in Patients with Acute Pancreatitis

Kahl¹,

Zimmermann²,

Pross³

et al. 2004

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Background: Several analgesics are in use for pain control in patients with acute pancreatitis. Procaine hydrochloride (procaine) has a long tradition and is recommended by the German Society of Gastroenterology and Metabolic Diseases for pain treatment in patients with acute pancreatitis. There is no controlled trial showing that procaine could be effective for pain treatment. Methods: In an open, randomized, controlled trial, 107 patients (76 male, 31 female; mean age 45 ± 12 years) were included and randomized either to receive procaine (n = 55) or pentazocine (n = 52) for pain relief. Procaine 2 g/ 24 h was administered by continuous intravenous infusion, pentazocine 30 mg was administered every 6 h as a bolus intravenous injection. Pentazocine was additionally administered on demand whenever required in patients of both treatment groups and its total consumption was recorded. Pain scores were assessed twice daily on a visual analogue scale. Results: Patients receiving procaine were significantly more likely to request additional analgesics compared to patients treated with pentazocine alone, 98 vs. 44%, respectively (p < 0.001). Procaine did not reduce the amount of pentazocine required for pain control. The amount of pentazocine given in both groups was not statistically significantly different. Recorded pain scores were significantly lower (p < 0.001) in patients in the pentazocine group during the first 3 days of analgesic treatment. From day 4 on there was no significant difference in pain scores among the two groups. Conclusion: Thus, intravenous procaine treatment is not effective for pain control in patients with acute pancreatitis.

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Section: Methodsmentioning

confidence: 99%

“…The drugs, tested in this study are recommended in several articles [3, 4, 5, 20]. Pentazocine belongs to the group of opioid agonists-antagonists.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Procaine Hydrochloride Fails to Relieve Pain in Patients with Acute Pancreatitis

Kahl¹,

Zimmermann²,

Pross³

et al. 2004

Digestion

View full text Add to dashboard Cite

show abstract

“…Since the protocol of this trial included procaine for pain as a mandatory baseline therapy the widespread knowledge about this approach is no longer surprising. When the same recommendations regarding procaine for pancreatitis pain resurfaced in various review articles and textbook chapters it slowly became conventional wisdom and even part of the German guidelines for the treatment of acute pancreatitis [2]. While the calcitonin trial could not demonstrate a significant treatment advantage for the compound under investigation it still had two lasting – and rather unexpected – effects: it established an effective network of clinical centres that continued to perform excellent multicentre pancreatitis trials and it inadvertently made intravenous procaine the standard pain treatment for pancreatitis patients.…”

Section: Introductionmentioning

confidence: 99%