Therapeutics for Equine Gastric Ulcer Syndrome

Zavoshti, Fereydon Rezazadeh; Andrews, Frank M.

doi:10.1016/j.cveq.2016.11.004

Cited by 18 publications

(18 citation statements)

References 73 publications

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“…This may be possible to achieve given the feeding methods that were described, for instance, access to ad libitum forage fed to the individual’s needs which would be monitored by staff, specialist concentrate feed, tailored to each horse and their level of work, fed three to four times a day and pasture turnout. Such an approach should mean there would rarely be an absence of food in the horse’s stomach buffering the presence of acid which is always present in the glandular region of the stomach [37].…”

Section: Discussionmentioning

confidence: 99%

Living the ‘Best Life’ or ‘One Size Fits All’—Stakeholder Perceptions of Racehorse Welfare

Butler

Valenchon

Annan

et al. 2019

Animals

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The purpose of the study was to explore the perceptions held by British racing industry stakeholders of factors influencing racehorse welfare. Ten focus groups were held across the UK with a total of 42 stakeholders from a range of roles within racehorse care including trainers, stable staff and veterinarians. Participants took part in three exercises. Firstly, to describe the scenarios of a ‘best life’ and the minimum welfare standards a horse in training could be living under. Secondly, to identify the main challenges for racehorse welfare and thirdly, to recall any innovative or uncommon practices to improve welfare they had witnessed. Using thematic analysis, eight themes emerged from the first exercise. Two strands, factors that contribute to maintaining health and the horse-human relationship ran through all eight themes. Across all themes horses living the ‘best life’ were perceived as being treated as individuals rather than being part of a ‘one size fits all’ life when kept under minimum welfare standards. Health was both perceived as the main challenge to welfare as well as one open to innovative practices such as improved veterinary treatments. Data obtained, informed by the knowledge and expertise of experienced stakeholders, combined with practical animal welfare science will be used to develop the first British racehorse welfare assessment protocol.

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Section: Discussionmentioning

confidence: 99%

Living the ‘Best Life’ or ‘One Size Fits All’—Stakeholder Perceptions of Racehorse Welfare

Butler

Valenchon

Annan

et al. 2019

Animals

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“…This usually occurs following overdose (high-dose administration), chronic administration, or in susceptible populations like foals 33. Omeprazole is the mainstay of treatment of gastric ulcers in humans and horses, and to date is the only drug (in paste formulations) for treatment and prevention of gastric ulcers in horses 34. In this case, it was administered to prevent gastric ulcers that could have impaired recovery.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Purkinje cell degeneration in a mule foal (Equus mulus mulus)

Suñol¹,

Fierro²,

Foiani

et al. 2018

Vet Record Case Reports

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A case of a mule foal with cerebellar Purkinje cell degeneration is described. A one-day-old mule foal was presented with lateral recumbency, obtunded mentation, poor metabolic status (general weakness, congestive mucous membranes, tachycardia, weak pulse, hypomotility and hypothermia) and cerebellar signs. After receiving medical treatment, the foal’s overall condition markedly improved but severe cerebellar ataxia and intention tremors were still present. Three weeks later, physical examination was normal but neurological signs had worsened and the foal was subjected to euthanasia. Postmortem findings revealed lesions consistent with corticocerebellar Purkinje cell degeneration. This is the first case report describing this condition in a mule.

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“…F I G U R E 7 Bar charts illustrate the 20 most abundant genera found in the feces and their cumulated relative abundance (%) in each of the 8 horses included in the study. Each bar represents a horse (1)(2)(3)(4)(5)(6)(7)(8). C0: control period, Day 0; C7: control period, Day 7; A0: administration period, Day 0; A7: administration period, Day 7 gastric mucosa was significantly different before and after omeprazole administration (P = .03).…”

Section: After Disinfection With a Quaternary Ammonium Solution (Umonmentioning

confidence: 98%

“…1 Omeprazole is the mainstay treatment of gastric ulcers in humans, dogs, and horses. 1,2 It is a potent inhibitor of gastric acid secretion, blocking the hydrogen-potassium-ATPase (proton pump) of gastric parietal cells, and allowing gastric pH to increase. 2 In equine practice, omeprazole is used to treat gastric ulcers and also commonly administered empirically for prevention of gastric disease, even without an established diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 It is a potent inhibitor of gastric acid secretion, blocking the hydrogen-potassium-ATPase (proton pump) of gastric parietal cells, and allowing gastric pH to increase. 2 In equine practice, omeprazole is used to treat gastric ulcers and also commonly administered empirically for prevention of gastric disease, even without an established diagnosis. 3 In human patients, treatment with PPIs is associated with profound changes in the gut microbiome and increased risk of enteric infections by Clostridioides difficile (formerly Clostridium difficile), Salmonella spp, Shigella spp, or Campylobacter spp.…”

Section: Introductionmentioning

confidence: 99%

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Effect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses

Cerri

Taminiau

Lusancay

et al. 2020

Veterinary Internal Medicne

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Background: Omeprazole administration is associated with changes in gastric and fecal microbiota and increased incidence of Clostridioides difficile enterocolitis in humans and dogs. Hypothesis/Objectives: Study purpose was to assess the effect of omeprazole on gastric glandular and fecal microbiota in healthy adult horses. Animals: Eight healthy horses stabled on straw and fed 100% haylage. Methods: Prospective controlled study. Transendoscopic gastric glandular biopsies, gastric fluid, and fecal samples were obtained from each horse twice at a 7-day interval before the administration of omeprazole. Samples were taken on the same horses before and after a 7-day administration of omeprazole (4 mg/kg PO q24h). pH was assessed on fresh gastric fluid and other samples were kept at −20 C until analysis. Bacterial taxonomy profiling was obtained by V1V3 16S amplicon sequencing from feces and gastric glandular biopsies. Analysis of alpha, beta diversity, and comparison between time points were performed with MOTHUR and results were considered significant when P < .05. Results: Gastric pH increased significantly after 7 days of omeprazole administration (P = .006). Omeprazole did not induce significant major changes in composition of fecal or gastric glandular microbiota, however, after administration, certain microbial genera became more predominant in the gastric glandular mucosa (lower Simpson's evenness, P = .05). Only the genus Clostridium sensu strictu_1 had a significant shift in the glandular gastric mucosa after omeprazole administration (P = .002). No population shifts were observed in feces. Conclusions and Clinical Importance: Oral administration of omeprazole could have fewer effects in gastrointestinal microbiota in the horse compared to other species.

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Therapeutics for Equine Gastric Ulcer Syndrome

Cited by 18 publications

References 73 publications

Living the ‘Best Life’ or ‘One Size Fits All’—Stakeholder Perceptions of Racehorse Welfare

Living the ‘Best Life’ or ‘One Size Fits All’—Stakeholder Perceptions of Racehorse Welfare

Cerebellar Purkinje cell degeneration in a mule foal (Equus mulus mulus)

Effect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses

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