Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts

Fedotova, Julia; Kubatka, Peter; Büsselberg, Dietrich; Shleikin, A.; Čaprnda, Martin; Dragašek, Jozef; Rodrigo, Luı́s; Pohanka, Miroslav; Gašparová, Iveta; Nosáľ, Vladimír; Opatřilová, Radka; Qaradakhi, Tawar; Zulli, Anthony; Kružliak, Peter

doi:10.1016/j.biopha.2017.08.107

Cited by 38 publications

(37 citation statements)

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“…While many drugs are used to treat anxiety including benzodiazepines, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors (Fedotova et al 2017a), they are often associated with adverse side effects that negatively impact one's basic activities and general quality of life (Koen and Stein 2011;Trindade et al 1998). Unfortunately, there are no particularly efficacious drugs on the market for preventing cognitive decline in individuals with mild cognitive impairment or AD (Atri 2019).…”

Section: Discussionmentioning

confidence: 99%

The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

Campos

Souza

et al. 2020

Cell Mol Neurobiol

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Women who have bilateral oophorectomies prior to the age of natural menopause are at increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type disorders. Clinical and animal studies indicate angiotensin type 1 receptor (AT 1 R) blockers (ARBs) have blood pressure (BP)-independent neuroprotective effects. To investigate the potential use of ARBs in normotensive women at increased risk of developing neurocognitive problems, we studied a rat model of bilateral oophorectomy. Long Evans rats were sham-operated (Sham) or ovariectomized (Ovx) at 3 months of age and immediately treated continuously with vehicle (Veh) or the ARB losartan (Los) for the duration of the experiment. In contrast to many hypertensive rat models, ovariectomy did not increase mean arterial pressure (MAP) in these normotensive rats. Ovariectomized rats spent less time in the open arms of the elevated plus maze (EPM) [(% total time): Veh, 34.1 ± 5.1 vs. Ovx, 18.7 ± 4.4; p < 0.05] and in the center of the open field (OF) [(s): Veh, 11.1 ± 1.7 vs. Ovx, 6.64 ± 1.1; p < 0.05]. They also had worse performance in the novel object recognition (NOR) test as evidenced by a reduction in the recognition index [Veh, 0.62 ± 0.04 vs. Ovx, 0.45 ± 0.03; p < 0.05]. These adverse effects of ovariectomy were prevented by Los. Losartan also reduced plasma corticosterone in Ovx rats compared to Veh treatment [(ng/mL): Ovx-Veh, 238 ± 20 vs. Ovx-Los, 119 ± 42; p < 0.05]. Ovariectomy increased AT 1 R mRNA expression in the CA3 region of the hippocampus (Hc) [(copies x 10 6 /µg RNA): Sham-Veh, 7.15 ± 0.87 vs. 9.86 ± 1.7; p < 0.05]. These findings suggest the neuroprotective effects of this ARB in normotensive Ovx rats involve reduction of plasma corticosterone and blockade of increased AT 1 R activity in the hippocampus. These data suggest ARBs have therapeutic potential for normotensive women at increased risk of developing cognitive and behavioral dysfunction due to bilateral oophorectomy prior to the natural age of menopause.

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Section: Discussionmentioning

confidence: 99%

The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

Campos

Souza

et al. 2020

Cell Mol Neurobiol

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“…Several animal models are described to assess anxiolytic potential, which evaluate either conditioned or unconditioned responses [ 9 ]. Conditioned responses are measured in the Vogel conflict (VC) and the four-plate-test (FP), where mild electroshocks are used to punish drinking or exploratory behavior, respectively [ 9 , 10 ]. Evaluation of unconditioned responses is accomplished using the elevated plus maze (EPM), the open field (OF), the holeboard (HB) or the light/dark exploration test (LD), where the aversion of rodents to elevated, open or brightly lit areas is determined [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Conditioned responses are measured in the Vogel conflict (VC) and the four-plate-test (FP), where mild electroshocks are used to punish drinking or exploratory behavior, respectively [ 9 , 10 ]. Evaluation of unconditioned responses is accomplished using the elevated plus maze (EPM), the open field (OF), the holeboard (HB) or the light/dark exploration test (LD), where the aversion of rodents to elevated, open or brightly lit areas is determined [ 10 ]. Other animal models to measure effects on anxiety and/or stress are the marble burying test (MB), the forced swim test (FS), the tail suspension test (TS) and stress-induced hyperthermia (SIH) [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Evaluation of unconditioned responses is accomplished using the elevated plus maze (EPM), the open field (OF), the holeboard (HB) or the light/dark exploration test (LD), where the aversion of rodents to elevated, open or brightly lit areas is determined [ 10 ]. Other animal models to measure effects on anxiety and/or stress are the marble burying test (MB), the forced swim test (FS), the tail suspension test (TS) and stress-induced hyperthermia (SIH) [ 10 , 11 ]. The open field test can also be used to assess locomotor activity (LMA) of the animals, determining the number of crossings, rears and grooms as well as the total distance travelled [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Structure-Dependent Activity of Natural GABA(A) Receptor Modulators

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2018

Molecules

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GABA(A) receptors are ligand-gated ion channels consisting of five subunits from eight subfamilies, each assembled in four hydrophobic transmembrane domains. This pentameric structure not only allows different receptor binding sites, but also various types of ligands, such as orthosteric agonists and antagonists, positive and negative allosteric modulators, as well as second-order modulators and non-competitive channel blockers. A fact, that is also displayed by the variety of chemical structures found for both, synthetic as well as nature-derived GABA(A)-receptor modulators. This review covers the literature for natural GABA(A)-receptor modulators until the end of 2017 and discusses their structure-activity relationship.

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“…Therapeutical strategies for anxiety-like behavior treatment continued by the works of Fedotova et al [20]. Here Julia Fedotova discussed vitamin D3 treatment differentially affect anxiety-like behavior in the old ovariectomized female rats treated with low dose of 17β-estradiol [21].…”

mentioning

confidence: 99%