Therapeutical Potential of 5-HT6 of Receptor Modulation in Neurological and Psychiatric Conditions

Abstract

This review examines the pharmacological effects of targeting 5-HT6 receptors, a subtype of serotonin receptors found primarily in the hippocampus. These receptors are essential for synaptic function, functional plasticity and various cognitive functions such as learning and memory. The review synthesizes the existing literature to investigate the potential therapeutic use of drugs targeting 5-HT6 receptors in neurological and psychiatric conditions, including Alzheimer's disease, schizophrenia, depression, anxiety, neurodegenerative diseases and pregnancy mood disorders. Although some preclinical studies suggest positive precognitive effects, these results have often conflicted with clinical research; therefore more work needs to be done on drug classification and therapeutic effect as well as dosage considerations.