Therapeutical effect of modified adamantane copolymer compounds: study of molecular mechanisms.

Abstract

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

“…Because of the known tendency of aminoadamantanes to penetrate lipid bilayers, they assumed the anti-HIV activity of 137 to be possibly associated with processes on the surface of the host cell, for example, interaction with opioid receptors. Polymeric compounds that incorporate aminoadamantane derivatives linked to polyanionic matrices (believed to enhance the membranotropic activity of the polymers) have also been described. , HIV-1 infection could be inhibited in several cell lines using the polymer, whereas amantadine and rimantadine were ineffective in control experiments. Other compounds tested in regard to anti-HIV activity were hydrazides like 138 and 139 .…”

Development of a Strategy of Influenza Virus Separation Based on Pseudoaffinity Chromatography on Short Monolithic Columns

“…It is known that polymers and, in particular, copolymers of VP are widely used in the medico-biological field. ,, It was assumed that water-soluble and biocompatible copolymer poly(MAG- co -VP- co -Ac) (Figure b) being used as a macromolecular spacer could provide a significant flexibility to a small specific ligand in comparison with its direct coupling or via protein coupling to the solid support. In this case, the formation of an affinity matrix consisted of three steps (Figure g): (1) covalent coupling of preliminary activated (aldehyde-bearing) copolymer, (2) formation the secondary aldehyde groups by periodate oxidation of vinylsaccharide residues, and (3) immobilization of SLA on a polymer backbone using a direct reaction between amino and aldehyde groups.…”