Therapeutic vulnerabilities of cancer stem cells and effects of natural products

Reisenauer, Keighley; Aroujo, Jaquelin; Tao, Yi‐Chen; Ranganathan, Santhalakshmi; Romo, Daniel; Taube, Joseph H.

doi:10.1039/d3np00002h

Cited by 4 publications

(1 citation statement)

References 367 publications

(543 reference statements)

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“…In 2023, Zhang et al showed that another harmine derivative effectively blocked TNBC growth and metastasis in mice, including the regulation of CSCs [138]. A more extensive review of natural products capable of regulating CSCs was recently published by Reisenauer et al [139]. Incidentally, harmine was also used to reduce TWIST1 activity in the model of ulcerative colitis described in the previous section [53].…”

Section: Drugs Targeting Emtmentioning

confidence: 99%

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases

Mirjat,

Kashif,

Roberts

2023

IJMS

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TWIST1 is a transcription factor that is necessary for healthy neural crest migration, mesoderm development, and gastrulation. It functions as a key regulator of epithelial-to-mesenchymal transition (EMT), a process by which cells lose their polarity and gain the ability to migrate. EMT is often reactivated in cancers, where it is strongly associated with tumor cell invasion and metastasis. Early work on TWIST1 in adult tissues focused on its transcriptional targets and how EMT gave rise to metastatic cells. In recent years, the roles of TWIST1 and other EMT factors in cancer have expanded greatly as our understanding of tumor progression has advanced. TWIST1 and related factors are frequently tied to cancer cell stemness and changes in therapeutic responses and thus are now being viewed as attractive therapeutic targets. In this review, we highlight non-metastatic roles for TWIST1 and related EMT factors in cancer and other disorders, discuss recent findings in the areas of therapeutic resistance and stemness in cancer, and comment on the potential to target EMT for therapy. Further research into EMT will inform novel treatment combinations and strategies for advanced cancers and other diseases.

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Section: Drugs Targeting Emtmentioning

confidence: 99%

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases

Mirjat,

Kashif,

Roberts

2023

IJMS

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The biomarkers for maintenance Cancer stem cell features can be applicable in precision medicine of head and neck squamous cell carcinoma

Shayan,

Ghiyasimoghaddam,

Mirkatuli

et al. 2024

Journal of Stomatology, Oral and Maxillofacial Surgery

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Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups

Yin,

Chen,

Luo

et al. 2024

Org. Lett.

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Arene-tethered diols constitute a valuable class of structural motifs of drug and bioactive natural product molecules. In this study, a regioselective protocol for olefination and arylation of arene-tethered 1,2-diols and 1,3-diols has been developed using easily foldable acetal structures for attaching pyridine and nitrile directing groups. The method overcomes the steric hindrance effect of the short-chain diols and affords products in high yield and regioselectivity. This efficient cascaded catalysis has been successfully utilized in the syntheses of natural products such as peucedanol, decursinol, and marmesin.

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Therapeutic vulnerabilities of cancer stem cells and effects of natural products

Abstract: Residual tumor burden and chemotherapy-resistance point to a need for drug leads active toward cancer stem cells. Just as natural products have led the way for current treatments, the potential for novel applications of these molecules remains high.

Cited by 4 publications

References 367 publications

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases

The biomarkers for maintenance Cancer stem cell features can be applicable in precision medicine of head and neck squamous cell carcinoma

Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups

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