Therapeutic vitamin delivery: Chemical and physical methods with future directions

Rejinold, N. Sanoj; Kim, Hye‐Kyoung; Isakovic, A. F.; Gater, Deborah L.; Kim, Yeu‐Chun

doi:10.1016/j.jconrel.2019.01.038

Cited by 16 publications

(5 citation statements)

References 183 publications

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“…independently extracted characteristics of the retrieved RCTs and outcomes of interest from full-text articles. Extracted data involved (1) the number of participants at each stage, (2) participant characteristics, (3) study characteristics (registry, design, ethical approval, country, funding), (4) administered dose of vitamin D3 and methods of delivery, (5) intervention duration, (6) washout period (whenever applicable), (7) participant recruitment sites, (8) assays and kits for determining 25(OH)D levels, (9) baseline and post-intervention results (including 25(OH)D, Ca, and parathyroid hormone (PTH) concentrations), (10) recorded adverse events, (11) drop-outs, and (12) analysis performed (intention-to-treat or per protocol).…”

Section: Data Exctractionmentioning

confidence: 99%

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

et al. 2020

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(1) Background: Vitamin D deficiency is an important public health concern and supplementation is common for this deficiency. Many different modes of delivering supplementation have been proposed in order to enhance absorption and utilization. The present review compared the efficacy of vitamin D3 buccal spray against other forms of supplementation delivery. (2) Methods: The protocol was registered at PROSPERO (CRD42019136146). Medline/PubMed, CENTRAL and clinicaltrials.gov were searched from their inception until September 2019, for randomized controlled trials (RCTs) that compare vitamin D3 delivery via sublingual spray against other delivery methods. Eligible RCTs involved humans, of any age and health status, published in any language that evaluated changes in plasma 25(OH)D concentrations. Three reviewers independently extracted data, assessed risk of bias (RoB) and the quality of the trials. (3) Results: Out of 9759 RCTs, four matched the predefined criteria. Intervention duration ranged from 30 days to 3 months whereas vitamin D3 dosage ranged between 800 and 3000 IU/day. One RCT advocated for the superiority of buccal spray in increasing plasma 25(OH)D concentrations, although several limitations were recorded in that trial. The rest failed to report differences in post-intervention 25(OH)D concentrations between delivery methods. Considerable clinical heterogeneity was observed due to study design, intervention duration and dosage, assays and labs used to perform the assays, population age and health status, not allowing for synthesis of the results. (4) Conclusions: Based on the available evidence, delivery of vitamin D3 via buccal spray does not appear superior to the other modes of delivery. Future RCTs avoiding the existing methodological shortcomings are warranted.

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Section: Data Exctractionmentioning

confidence: 99%

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

et al. 2020

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“…However, many studies into the clinical consequences of the lack of VitD are inconclusive (11)(12)(13)(14), and there is a great need for a more complete understanding of the complex biochemical and biophysical properties of this group of compounds (15,16). The development of improved formulations of vitamin D for delivery, including in oral administration, food fortification and for transdermal delivery (17)(18)(19), also remains a topic of interest.…”

Section: Introductionmentioning

confidence: 99%

Effect of cholecalciferol on unsaturated model membranes

Devarajan

Kim

Isakovic

et al. 2021

Chemistry and Physics of Lipids

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“…Microencapsulated vitamins are now available as vitamin sources for feed plants, and microencapsulated vitamins have greater stability during storage and processing [3][4][5]. Moreover, microencapsulated vitamins target their release in the small intestine to improve absorption efficiency [6] and regulate vitamin concentrations in the blood through a slow and controlled release in the gastrointestinal tract [6,7]. However, there is a lack of information on the absorption and bioavailability of microencapsulated vitamins in pigs.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

et al. 2020

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The objective of this study was to quantify the relative bioavailability of microencapsulated vitamins A and E in nursery pigs and compare the effects of vitamin forms and vitamin levels on the plasma vitamin content and growth performance of weaned piglets. In experiment (Exp.) 1, 12 nursery pigs (fitted with jugular catheters) were supplied at 0 h with non-microencapsulated or microencapsulated vitamin A and E. Blood samples were collected at 1, 3, 6, 9, 12, 16, 18, 21, 24, 27, 30, 36, 48, and 72 h after feeding to compare the bioavailability of oral vitamins A and E. In Exp. 2, a total of 216 crossbred weaned piglets were assigned to six treatments. This experiment was a 2 × 3 factorial arrangement, with two factors for vitamin forms (non-microencapsulated and microencapsulated) and three factors for vitamin levels (the National Research Council level of vitamins, 75% commercial recommendations of vitamins (CRV) level, and a 100% CVR level). In Exp. 1, the relative bioavailability of microencapsulated vitamin E was significantly greater than that of non-microencapsulated vitamin E. In Exp. 2, the pigs fed diets containing 75% or 100% CRV levels of vitamins increased their growth performance and plasma vitamin concentrations compared to the control group. In conclusion, microencapsulation can improve the bioavailability of vitamins, and supplementation with high levels of vitamins was able to improve the growth performance of the piglets.

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Therapeutic vitamin delivery: Chemical and physical methods with future directions

Cited by 16 publications

References 183 publications

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

Effect of cholecalciferol on unsaturated model membranes

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

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