Therapeutic values, chemical constituents and toxicity of Taiwanese Dysosma pleiantha – A review

Karuppaiya, Palaniyandi; Tsay, Hsin Sheng

doi:10.1016/j.toxlet.2015.05.004

Cited by 17 publications

(8 citation statements)

References 37 publications

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Section: Introductionmentioning

confidence: 99%

“…The genus Dysosma (Hance) Woodson (Berberidaceae) consists of seven herbaceous perennial species, all of which are endemic to China . Dysosma pleiantha (Hance) Woodson (also known as Bajiaolian) is an important threatened Chinese herbal medicine and is restricted in distribution to southeastern China and the island of Taiwan . Traditional Chinese herbal medicine doctors and herbal pharmacies in Taiwan and China usually recommend the smashed or sliced D. pleiantha rhizome stewed either with water or alcohol for general remedies including postpartum recovery, treatment of weakness, neck mass, acne, hepatoma, lumbago, snakebite, lymphadenopathy, condyloma accuminata, tumor growth, and dysmenorrhea .…”

Section: Introductionmentioning

confidence: 99%

“…Kaempferol and quercetin (a group of polyphenols) (Fig. B, C) are also active anticancer compounds accumulating copious amounts in D. pleiantha rhizome . These polyphenols are known to possess a wide range of biochemical and pharmacological activities, including antioxidant, anti‐inflammatory, anticancer, and cardioprotective .…”

Section: Introductionmentioning

confidence: 99%

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Enhanced production of podophyllotoxin, kaempferol, and quercetin from callus culture of Dysosma pleiantha (Hance) Woodson: An endangered medicinal plant

Karuppaiya

Tsay

2019

Biotech and App Biochem

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Dysosma pleiantha (Hance) Woodson is one of the endangered traditional Chinese medicinal herbs, highly valued for its medicinal properties by Taiwan's mountain tribes. The present study aims to develop an efficient protocol for callus biomass by optimizing suitable culture medium, carbon source culture condition, and enhanced production of pharmaceutically important podophyllotoxin, kaempferol, and quercetin from callus culture of D. pleiantha under the influence of different additives. Best callus induction was achieved in Gamborg's medium (B5) with 1 mg/L 2,4‐dichlorophenoxyacetic acid (2,4‐D) along with 0.2 mg/L kinetin under dark condition. Tender leaves of D. pleiantha showed the maximum of 86% callus induction among the different explants tested. Highest leaf callus proliferation was noted in B5 medium with 1 mg/L 2,4‐D incubated under complete darkness. In addition, it was found that B5 medium with 1 mg/L 2,4‐D along with 2 g/L peptone produced more leaf callus biomass and enhanced production of podophyllotoxin (16.3‐fold), kaempferol (12.39‐fold), and quercetin (5.03‐fold) compared to control. Therefore, D. pleiantha callogenesis can provide an alternative source for enhanced production of secondary compounds regardless of the exploitation of its natural plant population.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced production of podophyllotoxin, kaempferol, and quercetin from callus culture of Dysosma pleiantha (Hance) Woodson: An endangered medicinal plant

Karuppaiya

Tsay

2019

Biotech and App Biochem

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“…Improved production of molecules with pharmaceutical and/or nutraceutical application has been reported by Niu et al. [1] and Karuppaiya and Tsay [2]. Niu et al.…”

mentioning

confidence: 99%

“…[1] undertook a coordinated improvement of both carbon and nitrogen metabolism of Bacillus subtilis to increase production of N‐acetylglucosamine, a compound for arthritis treatment. Karuppaiya and Tsay [2] introduced a biotechnological approach that represents a promising alternative for producing secondary plant metabolites with recognized pharmaceutical properties (e.g., anticancer) thus avoiding extinction of threatened traditional medicinal plants. Saba et al.…”

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confidence: 99%

Editorial for the special issue on “Metabolic engineering”

Mazzoli

Liu

2020

Biotech and App Biochem

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Total saponins from stems and leaves of Panax quinquefolius L. ameliorate podophyllotoxin‐induced myelosuppression and gastrointestinal toxicity

Zhang

Li²,

Gao³

et al. 2021

Biomedical Chromatography

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Podophyllotoxin (POD), a natural lignan distributed in podophyllum species, possesses significant antitumor and antiviral activities. But POD often causes serious side effects, such as myelosuppression, gastrointestinal toxicity, neurotoxicity, hepatic and renal dysfunction, and even death, which not only hinder its clinical application but also threaten the patient's health. Therefore, an effective treatment against POD-induced toxicity is important. Our preliminary study found that the total saponins from the stems and leaves of Panax quinquefolius L. (PQS) could significantly reduce the death of mice caused by POD. To reveal how PQS can alleviate PODinduced toxicity, further study was needed. Peripheral blood cell analysis, diarrhea score, and histological examination demonstrated that PQS could relieve myelosuppression and gastrointestinal side effects induced by POD. Then, metabolomics was performed to investigate the possible protective mechanism of PQS on POD-induced myelosuppression and gastrointestinal toxicity. Metabolomics analysis showed that metabolic changes caused by POD could be reversed by PQS to some extent; 23 metabolites altered significantly after POD exposure, and 11 metabolites significantly reversed by PQS pretreatment. Metabolic pathway analysis suggested that PQS might exhibit its protective effects by rebalancing disordered arginine, glutamine, and unsaturated fatty acid metabolism.

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Therapeutic values, chemical constituents and toxicity of Taiwanese Dysosma pleiantha – A review

Cited by 17 publications

References 37 publications

Enhanced production of podophyllotoxin, kaempferol, and quercetin from callus culture of Dysosma pleiantha (Hance) Woodson: An endangered medicinal plant

Enhanced production of podophyllotoxin, kaempferol, and quercetin from callus culture of Dysosma pleiantha (Hance) Woodson: An endangered medicinal plant

Editorial for the special issue on “Metabolic engineering”

Total saponins from stems and leaves of Panax quinquefolius L. ameliorate podophyllotoxin‐induced myelosuppression and gastrointestinal toxicity

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