Therapeutic utilization of zinc supplementation concurrent with ozone therapy ameliorates diabetic foot ulcer and attenuates serum level of C-reactive protein- A case report study

Khorsandi, Layasadat; Dadfar, Reza; Goujani, Reza; Mousavi, SeyyedFarid; Aslani, Zahra

doi:10.4103/abr.abr_11_22

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In our study, the ozone therapy group exhibited lower levels of ESR, CRP, and PCT compared to the control group, indicating a potential role of ozone in reducing wound inflammation. These inflammatory markers, ESR, CRP, and PCT, have been previously associated with DFUs prognosis ( 21 – 23 ), aligning with other reports suggesting that ozone therapy can effectively reduce inflammation in DFUs ( 15 , 24 , 25 ).The underlying mechanism for these observations may involve the bactericidal effects of ozone. Ozone has the ability to eliminate bacteria within the wound, consequently reducing damage caused by bacterial colonization to the epithelial cells.…”

Section: Discussionsupporting

confidence: 85%

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Sun,

Heng,

Liu

et al. 2024

Front. Endocrinol.

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BackgroundThe availability of research on short-term ozone therapy for diabetic foot ulcers (DFUs) is limited, and even when it is accessible, it mainly comprises of basic analysis conducted during long-term ozone therapy. This study was to evaluate the efficacy of short-term ozone therapy in promoting wound healing in DFUs.MethodsA retrospective analysis was conducted on 89 patients with type 2 diabetes complicated by DFUs. The patients were divided into two groups: ozone therapy group (n=41) and control group (n=48). Wound condition, change of bacterial types, changes in inflammatory indicators (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and procalcitonin [PCT]), vascular endothelial growth factor (VEGF), cytokines [Interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α)], and oxidative stress levels (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [T-AOC]) were observed pre-treatment and after 1 week. After a 12-week of follow-up, wound healing rate, amputation rate, inpatient day, duration of antibiotics, reinfection rate, incidence of new ulcers, readmission rate, and reoperation rate, and cumulative wound healing rate using Kaplan-Meier curves were assessed.ResultsAfter 1 week of treatment, the ozone therapy group showed higher VEGF, SOD, and T-AOC levels compared to the control group (P<0.05), while CRP, PCT, ESR, IL-6, TNF-α, MDA levels and bacterial types were lower (P<0.05). The ozone therapy group had a higher wound healing rate after a 12-week follow-up (P<0.05). Kaplan-Meier curves indicated a higher cumulative wound healing rate in the ozone therapy group (P<0.05). Additionally, the ozone therapy group had lower inpatient day, duration of antibiotics, reinfection rate, and readmission rate compared to the control group (P<0.05).ConclusionShort-term ozone therapy is effective in promoting wound healing in DFUs by reducing inflammation, increasing growth factor levels, improving oxidative stress status, shortening healing time, and improving long-term prognosis. These findings suggest the potential of short-term ozone therapy as a valuable treatment modality for DFUs.

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