The study reveals that the synthesized Bhasma was converted into its nontoxic oxide form and had a highly reduced particle size observed from SEM images. These studies reveal that Vanga Bhasma prepared by traditional method of heating (Sn1) has 50% nanoparticles (150-300 nm range) that prepared by using electric muffle furnace (Sn2) has 100% nanoparticles (50-100 nm range) while commercial samples (Sn3) has 50% nanoparticles (100-300 nm range). Study also confirmed the formation of organometallic compound (SnO) at the end of the manufacturing process. The percentage bioaccessibility for gastrointestinal digestion is more than the gastric digestion. Hence, it is concluded that Vanga Bhasma can be useful nanomedicine.