Therapeutic Uses of Antioxidant Liposomes

Stone, William L.; Smith, Milton

doi:10.1385/mb:27:3:217

Cited by 61 publications

(36 citation statements)

References 114 publications

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“…An advantage of this strategy compared with chemically modified drugs is that active molecules are encapsulated without modifying their molecular structure, which preserves the drug's pharmacodynamics profile. When employed in antioxidant therapy, lisposomes are constituted by phosphatidylcholine, phosphatidylglycerol, and cholesterol, and further include molecular antioxidants, antioxidant enzymes, or a combination of various agents with antioxidant activities (308). It appears that antioxidants such as quercetin, the liposomally encapsulated NAC (4), and Siliphos (a complex formed by silybin and phospholipids) have therapeutic effects in a model of sepsis.…”

mentioning

confidence: 99%

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Apostolova

Víctor

2015

Antioxidants & Redox Signaling

232

147

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Mitochondrial function and specifically its implication in cellular redox/oxidative balance is fundamental in controlling the life and death of cells, and has been implicated in a wide range of human pathologies. In this context, mitochondrial therapeutics, particularly those involving mitochondria-targeted antioxidants, have attracted increasing interest as potentially effective therapies for several human diseases. For the past 10 years, great progress has been made in the development and functional testing of molecules that specifically target mitochondria, and there has been special focus on compounds with antioxidant properties. In this review, we will discuss several such strategies, including molecules conjugated with lipophilic cations (e.g., triphenylphosphonium) or rhodamine, conjugates of plant alkaloids, amino-acid-and peptide-based compounds, and liposomes. This area has several major challenges that need to be confronted. Apart from antioxidants and other redox active molecules, current research aims at developing compounds that are capable of modulating other mitochondria-controlled processes, such as apoptosis and autophagy. Multiple chemically different molecular strategies have been developed as delivery tools that offer broad opportunities for mitochondrial manipulation. Additional studies, and particularly in vivo approaches under physiologically relevant conditions, are necessary to confirm the clinical usefulness of these molecules. Antioxid. Redox Signal. 22, 686-729.

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mentioning

confidence: 99%

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Apostolova

Víctor

2015

Antioxidants & Redox Signaling

232

147

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“…Antioxidant liposomes hold great promise in the treatment of many diseases in which oxidative stress plays a significant role (Stone and Smith 2004). A major problem associated with conventional liposomes is that they are recognized by the immune system as foreign substances and rapidly removed by phagocytic cells of the reticuloendothelial system (Ratnam et al 2006).…”

Section: Nano-antioxidant Pharmacotherapymentioning

confidence: 99%

Treating Retinopathies – Nanotechnology as a Tool in Protecting Antioxidants Agents

Silva¹,

Borges²,

Ramos³

et al. 2014

Systems Biology of Free Radicals and Antioxidants

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“…enzim ve proteinleri) içeren lipozomlar için kullanılmaktadır [14]. Son yıllarda, antioksidan lipozomların oksidatif stres ile ilişkilendirilen bazı hastalıkların tedavisinde yararlı olabileceğine yönelik bulgular elde edilmiştir [15][16][17].…”

Section: Tartışma Ve Sonuçunclassified

C vitamini, E vitamini ve polifenol ekstresi içeren lipozomların eldesi ve antioksidan aktivitelerinin karşılaştırılması

Oskouei¹,

Biçim²,

Yalçın³

2014

Marmara Medical Journal

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ÖZETMaterials and Methods: Different preparative techniques such as thin-film hydration, reverse-phase evaporation, freezethaw and periodic sonication were used to produce liposomes. These methods were used to encapsulate different antioxidant molecules and were compared for antioxidant activity. Light microscopy, fluorescence microscopy and particle size analyzers were used in order to characterize the prepared liposomes and to analyze their particle size, distribution and shape.Results: Liposomes containing water-soluble antioxidants such as vitamin C and polyphenols and fat-soluble antioxidant vitamin E were prepared. The separation of free molecules from those that were liposomed was performed with Sephadex G-25 gel filtration chromatography. The antioxidant activity of vitamin E liposomes was highest in comparison to the others.Conclusion: Among the methods we have used for preparing liposomes sonication is the fastest and also most advantageous because organic solvents such as methanol or chloroform are not used during preparation. Both water-soluble antioxidant molecules and lipid-soluble antioxidants could be prepared with this method and preserved their activities.

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Therapeutic Uses of Antioxidant Liposomes

Cited by 61 publications

References 114 publications

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

Treating Retinopathies – Nanotechnology as a Tool in Protecting Antioxidants Agents

C vitamini, E vitamini ve polifenol ekstresi içeren lipozomların eldesi ve antioksidan aktivitelerinin karşılaştırılması

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