Therapeutic Use of Microbubbles and Ultrasound in Acute Peripheral Arterial Thrombosis: A Systematic Review

Nederhoed, J.H.; Tjaberinga, Meike; Otten, René; Evers, Josje M.; Musters, René J.P.; Wisselink, Willem; Yeung, Kak Khee

doi:10.1016/j.ultrasmedbio.2021.06.001

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…In the field of biomedicine, ultrasound-accelerated thrombolysis has recently emerged as a promising technique for treating thrombosis by transmitting sound waves to blood clots [ 48 – 50 ]. Currently, common ultrasound thrombolysis equipment is based on focusing the ultrasound transducer structure, which requires accurate focus control during the treatment process.…”

Section: Resultsmentioning

confidence: 99%

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

Zhang,

Li,

et al. 2024

Nano-Micro Lett.

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Compared with traditional piezoelectric ultrasonic devices, optoacoustic devices have unique advantages such as a simple preparation process, anti-electromagnetic interference, and wireless long-distance power supply. However, current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency, which seriously hinder their widespread applications. In this study, using a self-healing polydimethylsiloxane (PDMS, Fe-Hpdca-PDMS) and carbon nanotube composite, a flexible optoacoustic patch is developed, which possesses the self-healing capability at room temperature, and can even recover from damage induced by cutting or laser irradiation. Moreover, this patch can generate high-intensity ultrasound (> 25 MPa) without the focusing structure. The laser damage threshold is greater than 183.44 mJ cm−2, and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66 × 10−3, compared with other carbon-based nanomaterials and PDMS composites. This patch is also been successfully examined in the application of acoustic flow, thrombolysis, and wireless energy harvesting. All findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

Zhang,

Li,

et al. 2024

Nano-Micro Lett.

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“…A recent analysis [ 91 ] of studies using MBs and ultrasound in peripheral arterial thrombosis reviewed eight clinical stroke studies, including two case series [ 92 , 93 ]. There was high heterogeneity among the studies, which made it impossible to perform a meta-analysis.…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

Sonothrombolysis for Ischemic Stroke

Venketasubramanian,

Yeo,

Tan

et al. 2024

JCDD

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Stroke is a major cause of death and disability globally, with ischemic stroke being the predominant mechanism. While spontaneous recanalization may occur, significant neuronal injury would have occurred in the interim. Intravenous thrombolysis administered within the first 4.5 h after stroke onset and endovascular thrombectomy within 24 h in patients with a salvageable penumbra improves functional independence. Ultrasound has been shown in both in vivo and in vitro models to enhance clot lysis, even more-so in the presence of thrombolytic agents. The use of transcranial Doppler and transcranial color-coded Doppler ultrasound in acute IS has been reported in case series, case-controlled studies, and clinical trials. While ultrasound at a frequency of 300 kHz increases the risk of intracranial hemorrhage, the 2 MHz range ultrasound aids thrombolysis and improves recanalization without significantly increasing the risk of symptomatic intracranial hemorrhage. Despite this, functional independence was not increased in clinical trials, nor was a benefit shown with the adjunctive use of microbubbles or microspheres. Nonetheless, newer technologies such as endovascular ultrasound, endovascular delivery of microbubbles, and thrombolytic-filled microbubbles await clinical trials. More evidence is needed before sonothrombolysis can be routinely used in the hyperacute management of ischemic stroke.

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“…Its mechanisms include thrombus fragmentation and augmented penetration of thrombolytic agents [ 112 ]. A systematic review included 35 studies and found that the recanalization rates in the group that conducted sonothrombolysis were higher, suggesting that combined microbubbles and ultrasound is a safe and effective strategy for thrombosis treatment [ 113 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound

Zhao

Deng

et al. 2022

Pharmaceutics

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Ultrasound with low frequency (20–100 kHz) assisted drug delivery has been widely investigated as a non-invasive method to enhance the permeability and retention effect of drugs. The functional micro/nanobubble loaded with drugs could provide an unprecedented opportunity for targeted delivery. Then, ultrasound with higher intensity would locally burst bubbles and release agents, thus avoiding side effects associated with systemic administration. Furthermore, ultrasound-mediated destruction of micro/nanobubbles can effectively increase the permeability of vascular membranes and cell membranes, thereby not only increasing the distribution concentration of drugs in the interstitial space of target tissues but also promoting the penetration of drugs through cell membranes into the cytoplasm. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theragnostic tool. In this review, we first discuss the structure and generation of micro/nanobubbles. Second, ultrasound parameters and mechanisms of therapeutic delivery are discussed. Third, potential biomedical applications of micro/nanobubble-assisted ultrasound are summarized. Finally, we discuss the challenges and future directions of ultrasound combined with micro/nanobubbles.

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Therapeutic Use of Microbubbles and Ultrasound in Acute Peripheral Arterial Thrombosis: A Systematic Review

Cited by 6 publications

References 55 publications

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

Sonothrombolysis for Ischemic Stroke

Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound

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