Therapeutic use of H2O2-responsive anti-oxidant polymer nanoparticles for doxorubicin-induced cardiomyopathy

Park, Seunggyu; Yoon, Jooheung; Bae, Soochan; Park, Minhyung; Kang, Changsun; Ke, Qingen; Lee, Dongwon; Kang, Peter M.

doi:10.1016/j.biomaterials.2014.03.084

Cited by 79 publications

(62 citation statements)

References 41 publications

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“…Hydrogen peroxide (H 2 O 2 ) is the most abundant form of ROS produced during ischemia/reperfusion, which usually induces the release of pro-inflammatory cytokines and triggers apoptosis, leading to the oxidative damage of tissues. [116][117][118] Therefore, targeting H 2 O 2 as a diagnostic marker and therapeutic agent shows great potentials.…”

Section: H 2 O 2 -Responsive Drug Deliverymentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

196

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Section: H 2 O 2 -Responsive Drug Deliverymentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

196

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“…Cytochrome P450, an important enzyme for biotransformation of endogenous and exogenous chemical compounds, has been reported to be important for producing ROS [24]. Elevation of ROS production leads lipid peroxidation, reduces protein synthesis, and induces apoptosis due to loss of mitochondrial membrane potential and p53 activity [30]. ADR has previously been shown to induce inflammation in some cancer line by elevation of some inflammatory markers, e.g., IL-1, TNF-α, and NF-KB.…”

Section: Discussionmentioning

confidence: 99%

“…NF-κB is related to both survival and cell death pathways. ADR was reported to increase NF-κB activation in case of liver failure [30]. NF-κB is able to trigger apoptosis by activating some proapoptotic proteins such as p53, Fas, Fas ligand, and death receptor [38].…”

Section: Discussionmentioning

confidence: 99%

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Yapışlar

Taşkın

Ozdas

et al. 2015

Biol Trace Elem Res

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Growing evidence has been reported on adriamycin (ADR) hepatotoxicity in literature. Hepatotoxicity caused by the use of drugs has a serious undesirable effect in the cure of cancer patients that needs to be eliminated. The exact mechanism of ADR on non-cancerous tissue still remains to be a mystery. The zeolite (clinoptilolite) minerals form a complex group of aluminosilicates that often occur as accessory minerals in intermediate and basic rocks. In light of this information, we investigated the possible anti-inflammatory and anti-apoptotic effects of clinoptilolite in ADR that is inducing the toxicity in primary liver cell culture. Primary liver cell culture from rat was used in the study. We had three experiment groups including the following: (1) cells treated only with 50 μM ADR for 24 h, (2) cells treated with the 50 μM ADR for 24 h and then treated with 10(-4) M zeolite for 1 h, and (3) cells were incubated with 50 μM ADR for 24 h and then incubated with 10(-4) M zeolite for 24 h to test its long-term effects. After that, western blotting was performed in order to evaluate protein expression levels of several inflammation markers including IL-1β, tumor necrosis factor (TNF)-α, and nuclear factor kappa B (NF-κB), and immunohistochemistry was carried out to detect apoptosis in liver cell culture. Also, TdT-dUTP Terminal Nick-End Labeling (TUNEL) method was used for detecting apoptosis. We found elevated levels of inflammatory protein and apoptotic markers in ADR-administered cells (p < 0.05). Inflammatory and apoptotic markers decreased significantly after treated with zeolite (p < 0.05). The present study was pointed out that ADR causes hepatotoxicity via apoptosis and/or inflammation processes resulting from initiator NF-κB and TNF which causes proinflammatory mediators such as IL-1β. Elevation of inflammation might give rise to trigger apoptosis. Clinoptilolite counteracted the apoptosis and inflammation induced by ADR arising from the decrease in NF-κB, TNF-α, and IL-1β protein levels.

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“…However, clinical studies have shown its serious side effects, such as dose-dependent cardiotoxicity and hepatotoxicity. 3 Previous researches recently have revealed that nano-sized carrier enhance the accumulation of Dox in the tumor site and decrease the side effect. 4,5 Intra-arterial administration of therapeutic radiopharmaceuticals and chemotherapeutic agents can deliver a tumoricidal dose with less non-tumorous hepatic tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and scintigraphic applications of polymeric micelles: combination of chemotherapy and radiotherapy in hepatocellular carcinoma

Shih¹,

Peng²,

Chiang³

et al. 2015

IJN

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This study evaluated a multifunctional micelle simultaneously loaded with doxorubicin (Dox) and labeled with radionuclide rhenium-188 ( 188 Re) as a combined radiotherapy and chemotherapy treatment for hepatocellular carcinoma. We investigated the single photon emission computed tomography, biodistribution, antitumor efficacy, and pathology of 188 Re-Dox micelles in a murine orthotopic luciferase-transfected BNL tumor cells hepatocellular carcinoma model. The single photon emission computed tomography and computed tomography images showed high radioactivity in the liver and tumor, which was in agreement with the biodistribution measured by γ-counting. In vivo bioluminescence images showed the smallest size tumor ( P <0.05) in mice treated with the combined micelles throughout the experimental period. In addition, the combined 188 Re-Dox micelles group had significantly longer survival compared with the control, 188 ReO 4 alone ( P <0.005), and Dox micelles alone ( P <0.01) groups. Pathohistological analysis revealed that tumors treated with 188 Re-Dox micelles had more necrotic features and decreased cell proliferation. Therefore, 188 Re-Dox micelles may enable combined radiotherapy and chemotherapy to maximize the effectiveness of treatment for hepatocellular carcinoma.

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Therapeutic use of H2O2-responsive anti-oxidant polymer nanoparticles for doxorubicin-induced cardiomyopathy

Cited by 79 publications

References 41 publications

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Therapeutic and scintigraphic applications of polymeric micelles: combination of chemotherapy and radiotherapy in hepatocellular carcinoma

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