Therapeutic use of Fisetin and Fisetin Loaded on Mesoporous Carbon Nanoparticle (MCN) in Thioglycollate-induced Peritonitis

Abstract

Background: The pathophysiology of aseptic peritonitis involves inflammation of the serosal membrane that lines the abdominal cavity and the organs contained therein. The etiology of peritonitis is complicated and is involved in various processes, of which, the most important one is the inflammatory reaction. During the pathological process of peritonitis, NF-κB plays an activating role in the inflammatory reaction, which might be a potential therapeutic target in the therapy of certain inflammatory diseases. We studied the anti-inflammatory and pro-regenerative actions of Fisetin, a flavonol found in many plants, in a mouse model of thioglycollate-induced peritonitis, as well as the actions of fisetin administered with a nanoparticle such as mesoporous carbon nanoparticle (MCN). BALB/c mice were used in this study.

Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation

“…3,7,3',4'-Tetrahydroxyflavone (fisetin), a naturally occurring bioactive flavonol, has been reported to improve the development of various diseases with its multiple bioactivities, including the reduction of oxidative stress, inflammatory response and apoptosis ( 15 - 17 ). In addition, fisetin was reported to ameliorate immune cell infiltration to improve organ injury ( 18 ).…”