Therapeutic targets of triple‐negative breast cancer: a review

Jamdade, Vinayak S; Sethi, N.; Mundhe, Nitin; Kumar, Parveen; Lahkar, Mangala; Sinha, Neeraj

doi:10.1111/bph.13211

Cited by 176 publications

(130 citation statements)

References 72 publications

(73 reference statements)

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“…The Wnt receptor frizzled-7 (FZD7) and co-receptor the low-density lipoprotein receptor-related protein-6 (LRP6) expression increased significantly in triple-negative breast cancer. Moreover, the transcriptional knockdown of FZD7 or LRP6 in triple-negative breast cancer cells represses tumor growth (Jamdade et al, 2015). Accumulating evidence demonstrated that activated Wnt/ -catenin signaling participates in the pathological process of breast cancer (King et al, 2012;Lu and Li, 2014;Ma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling

Chen

2018

Bangladesh J Pharmacol

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Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling BJP IntroductionBreast cancer is the second leading cause of cancer death among women after lung cancer in the United States (DeSantis et al., 2014). In the treatment for breast cancer, some adverse effects could cause serious complications and affect the health and quality of life among survivors (Odle, 2014). Therefore, it is necessary to develop novel anti-cancer candidates for breast cancer.In the past several decades, natural compounds such as resveratrol (Sinha et al., 2016), epigallocatechin-3-gallate, oldenlandia diffusa and Ziziphus jujube have been demonstrated that possessed potential anti-breast cancer activity (Bonofiglio et al., 2016).Lycorine, known as a multifunctional compound, is extensively studied for its pharmacological activities, such as anti-tumor activity (Lamoral-Theys et al., 2010). Previous studies have shown that lycorine presented a potential anti-cancer activity in breast cancer via the inhibition of tumor growth and metastasis Ying et al., 2017). Src/FAK (focal adhesion kinase) -involved pathway and STAT3 (signal transducer and activator of transcription 3) signaling pathway were involved in growth, invasion and metastasis of breast cancer.However, Wnt/ -catenin signaling, a multifunctional pathway that has not been studied to be involved in proliferation, invasion and migration of breast cancer. This study is meant to confirm the inhibitory effects of lycorine on the proliferation, migration and invasion of MDA-MB-231 breast cancer cells and investigate the activation of Wnt/ -catenin signaling pathway involved. Materials and Methods Cell lines and reagentsHuman MDA-MB-231 breast cancer cells were obtained AbstractThis study was aimed to determine the effects of lycorine, a toxic crystalline alkaloid, on MDA-MB-231 breast cancer cells proliferation, migration and invasion, and to investigate the mechanism involved. The cells were cultured with different concentrations of lycorine in vitro. MTT assays were performed to determine the proliferation of cells. Transwell assays were performed to measure the migration and invasion of cells. The activation of Wnt/ -catenin signaling pathway and expression were assayed by Western blot. This study showed that proliferation, migration and invasion of MDA-MB-231 breast cancer cells could be inhibited by lycorine. Furthermore, we found that Wnt/ -catenin signaling was markedly blocked in MDA-MB-321 cells treated with lycorine. In conclusion, lycorine inhibits the proliferation, migration and invasion of MDA-MB-231 breast cancer cells that is associated with the suppression of Wnt/ -catenin signaling. Article Info

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Section: Discussionmentioning

confidence: 99%

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling

Chen

2018

Bangladesh J Pharmacol

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“…Since m-TOR pathway not only plays a key role in glycolysis, but also acts as therapeutic target of TNBC [26], we further examined the effect of curcumin on m-TOR phosphorylation in MDA-MB-231 cells. Curcumin alone partly reduced phosphroylated m-TOR.…”

Section: Discussionmentioning

confidence: 99%

Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway

Geng

Ding

et al. 2016

Biochemical and Biophysical Research Communications

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“…The level of BMP and Hedgehog signalling was higher in triple negative than triple positive tumours that may also be facilitated by short variants or the balance of full length and shorter variants in these tumours. Enhanced Wnt signalling and Notch signalling has also been reported to play a role in triple negative tumours (Jamdade VS et al 2015;Koval A et al 2016;King TD et al 2012) although Wnt signalling is believed to be promoted by full length Sulf1 and Sulf2 genes.…”

Section: Discussionmentioning

confidence: 99%

Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling

Gill

Mehra

Milford

et al. 2016

Histochem Cell Biol

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Therapeutic targets of triple‐negative breast cancer: a review

Cited by 176 publications

References 72 publications

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling

Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway

Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling

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