Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment
Xianjun Li,
Tianjun Chen,
Xuehan Li
et al.
Abstract:Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of particular antigens, has emerged as one of the most rapidly advancing modalities in immunotherapy, demonstrating substantial success against hematological malignancies. However, previous generations of CAR-T cell therapy encountered numerous challenges in treating solid tumors, such as the lack of suitable targets, high immunosuppression, suboptimal persistence, and insufficient infiltration ow… Show more
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