Therapeutic Targeting of Eosinophil Adhesion and Accumulation in Allergic Conjunctivitis

Baiula, Monica; Bedini, Andrea; Carbonari, Gioia; Dattoli, Samantha Deianira; Spampinato, Santi Mario

doi:10.3389/fphar.2012.00203

Cited by 18 publications

(15 citation statements)

References 61 publications

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“…Herein we describe the use of the Amo α/β‐dipeptide scaffold for the design of stable peptidomimetic antagonists of the integrin α4β1, or very late activation antigen‐4 (VLA‐4), a heterodimeric cell‐surface receptor expressed on lymphocytes, monocytes, eosinophils, basophils, macrophages. The integrin α4β1 has been suggested to be involved in inflammatory processes associated with the sustained recruitment of these cells, and targeted by monoclonal α4 integrin antibodies and small‐molecule antagonists, which may find applications as anti‐inflammatory agents.…”

Section: Introductionmentioning

confidence: 99%

5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists

et al. 2015

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Peptidomimetics represent an attractive starting point for drug discovery programs; in particular, peptidomimetics that result from the incorporation of a heterocycle may take advantage of increased enzymatic stability and higher ability to reproduce the bioactive conformations of the parent peptides, resulting in enhanced therapeutic potential. Herein, we present mimetics of the α4β1 integrin antagonist BIO1211 (MPUPA-Leu-Asp-Val-Pro-OH), containing a aminomethyloxazolidine-2,4-dione scaffold (Amo). Interestingly, the retro-sequences PhCOAsp(OH)-Amo-APUMP including either (S)- or (R)-configured Amo displayed significant ability to inhibit the adhesion of α4β1 integrin expressing cells, and remarkable stability in mouse serum. Possibly, the conformational bias exerted by the Amo scaffold determined the affinity for the receptors. These peptidomimetics could be of interest for the development of small-molecule agents effective against inflammatory processes and correlated autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%

5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists

et al. 2015

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“…The contained ginsenosides can exert a controlled glucocorticoid-like effect. 29,30 Safety issues associated with long-term administration of KRG should be considered. A multicenter, double-blind, randomized, placebo-controlled trial, involving 100 patients and conducted over a 24-week period, revealed no significant differences in adverse events between KRG and placebo groups.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis

Jung

Kang

et al. 2020

Ear Nose Throat J

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Korean red ginseng (KRG) has been traditionally used in Korea for health improvement. However, the clinical effect of KRG intake on the symptoms in patients with allergic rhinitis remains unknown. Our study was performed to identify the clinical effects of KRG on patients with allergic rhinitis and to examine the effect of KRG on allergic inflammatory reaction. We evaluated 60 patients with allergic rhinitis. All the patients were treated for 4 weeks. The patients were divided into 3 groups, according to the medication. Twenty patients were treated with KRG, 20 patients with the placebo, and 20 patients with the antihistamine. The patients recorded their symptoms in a daily symptom diary card. The patients checked the peak nasal inspiratory flow rate 2 times a day. Total serum immunoglobulin E (IgE) and serum-specific IgE were measured by ImmunoCap method before and after 4-week medication. The Th2 cytokines interleukin-4 (IL-4), IL-5, and IL-10 were checked in the serum before and after the 4-week treatment. The eosinophil counts in the nasal smears were checked. Korean red ginseng group has shown the significant improvement in rhinorrhea, nasal itching, and eye itching. Both the antihistamine and KRG groups showed a significant decrease in total IgE level at the end of treatment. The serum IL-4 level and eosinophil counts in the nasal smears were significantly decreased both in the antihistamine and in the KRG groups. In conclusion, KRG might be a useful treatment modality for patients with allergic rhinitis.

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“…As CAPT is an in vivo diagnosis procedure, the application of the allergen is not appropriate for pregnant or lactating women, as well as patients affected by uncontrolled diseases, particularly uncontrolled asthma, and severe systemic diseases such as autoimmune, heart and vascular diseases (e.g. uncontrolled hypertension, in case adrenaline is needed to treat an adverse event), hyperthyroidism, severe liver or renal insufficiencies and ongoing malignancies . Conjunctival allergen provocation test is not recommended in patients suspected of allergy to drugs used for the CAPT procedure (e.g.…”

Section: Indications and Contraindications Of The Captmentioning

confidence: 99%

Conjunctival allergen provocation test : guidelines for daily practice

Fauquert

Jędrzejczak-Czechowicz

Rondón

et al. 2016

Allergy

102

142

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Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Indications are diagnosing the allergen(s)-triggering symptoms in IgE-mediated ocular allergy in seasonal, acute or perennial forms of allergic conjunctivitis, especially when the relevance of the allergen is not obvious or in polysensitized patients. Contraindications are limited to ongoing systemic severe pathology, asthma and eye diseases. CAPT should be delayed if receiving systemic steroids or antihistamines. Local treatment should be interrupted according to the half-life of each drug. Prerequisites are as follows: obtaining informed consent; evidencing of an allergen by skin prick tests and/or serum-specific IgE dosages; being able to deal with an unlikely event such as acute asthma exacerbation, urticaria or anaphylaxis, or an exacerbation of allergic conjunctivitis. Allergen extracts should be diluted locally prior to administration. Positive criteria are based on itching or quoted according to a composite score. An alternative scoring is based on itching. CAPT remains underused in daily practice, although it is a safe and simple procedure which can provide valuable clinical information.The conjunctival allergen provocation test (CAPT), also known as conjunctival allergen challenge (CAC), is a conjunctival provocation test (CPT) used to evaluate the inflammatory effects on the external ocular surface after the topical application of an allergen in a presumed sensitized patient. The aim was to objectively evaluate the reactivity to specific allergens at the mucosal surface (1).As stated in a recent Position Paper on Ocular Allergy, CAPT is a method for investigating the ocular surface IgE-mediated hypersensitivity disorders. It is used to determine or confirm which allergen(s) triggers the ocular symptoms, using the eye as a model to evidence a specific reactivity to allergen(s) (2). Conjunctival allergen provocation test is also a tool for investigating allergic inflammation mechanisms and biomarkers of the ocular surface, as well as its treatments. Recently, it has been used as a surrogate test of mucosal reactivity in other allergic diseases, namely rhinitis, asthma, food and latex allergy (3-5).Allergy 72 (2017) 43-54

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Therapeutic Targeting of Eosinophil Adhesion and Accumulation in Allergic Conjunctivitis

Cited by 18 publications

References 61 publications

5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists

5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists

The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis

Conjunctival allergen provocation test : guidelines for daily practice

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