Therapeutic Target Identification and Drug Discovery Driven by Chemical Proteomics
Mingjie Zou,
Haiyuan Zhou,
Letian Gu
et al.
Abstract:Throughout the human lifespan, from conception to the end of life, small molecules have an intrinsic relationship with numerous physiological processes. The investigation into small-molecule targets holds significant implications for pharmacological discovery. The determination of the action sites of small molecules provide clarity into the pharmacodynamics and toxicological mechanisms of small-molecule drugs, assisting in the elucidation of drug off-target effects and resistance mechanisms. Consequently, inno… Show more
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