Therapeutic surfactant-stripped frozen micelles

Zhang, Yumiao; Song, Wei; Geng, Jumin; Chitgupi, Upendra; Unsal, Hande; Federizon, Jasmin; Rzayev, Javid; Sukumaran, Dinesh K.; Alexandridis, Paschalis; Lovell, Jonathan F.

doi:10.1038/ncomms11649

Cited by 75 publications

(73 citation statements)

References 43 publications

(41 reference statements)

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“…[30–32] The process makes use of Pluronic surfactant, which is converted to unimeric form at low temperatures, and is then selectively stripped away with low temperature membrane processing, leaving behind ss-InFroMs with extremely high optical absorption in the near infrared (NIR). This approach provided contrast for functional photoacoustic computed tomography (PACT) of intestine.…”

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confidence: 99%

Surfactant‐Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

et al. 2016

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A gut imaging contrast agent would benefit from the following: 1) being edible and generally regarded as safe; 2) transiting stably through the intestine; and 3) activity in multiple modalities. We found that Chlorophyll-a (Chl), a plant pigment that is ubiquitous in human diets, was amenable to formulation in surfactant-stripped induced frozen micelles (ss-InFroMs). However, Chl ss-InFroM stability was limited in gastric conditions in vitro and in vivo. By demetallating Chl to generate pheophytin-a (Pheo), more stable ss-InFroms were obtained which exhibited complete fecal excretion following oral gavage without systemic absorption. Because ss-InFroms could be concentrated to high concentration during the low-temperature stripping of the loose Pluronic surfactant, Pheo ss-InFroMs were used for non-invasive photoacoustic computed tomography of the gut of mice. Unexpectedly, Pheo (but not Chl) ss-InFroms exhibited strong near infrared fluorescence, further enabling non-invasive fluorescence gut imaging. Since Pheo (but not Chl) could be chelated with exogenous metals, Pheo ss-InFroMs could be seamlessly post-labeled with 64Cu for whole body positron emission tomography. Taken together, these results underscore the potential for Pheo, as an edible material, to be re-formulated for higher-order multimodal gut imaging.

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confidence: 99%

Surfactant‐Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

et al. 2016

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“…Several drugs are used in cancer treatment, like doxorubicin (DOX), methotrexate (MTX) and cabazitaxel (CTX). [34, 35] However, chemotherapy often requires several doses, which may cause significant side effects. Another treatment method is photothermal therapy.…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Advanced Functional Nanomaterials for Theranostics

Huang

Lovell

2016

Adv Funct Materials

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Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more relevant animal disease models, thereby increasing potential for clinical translation. Current interests include non-invasive imaging of diseases, biomarkers and targeted delivery of therapeutic drugs. Here, we discuss some general design considerations of advanced theranostic materials and challenges of their use, from both diagnostic and therapeutic perspectives. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon-based nanoparticles and organic dye-based nanoparticles, have demonstrated potential for both diagnosis and therapy. Variations such as size control and surface modifications can modulate biocompatibility and interactions with target tissues. The needs for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research in the near future.

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“…9,10 Regardless of photophysical properties, injectable Pc and Ncs require solubilization to avoid very large aggregates, which would cause adverse injection reactions. 11 To overcome the poor water solubility, many solubilization strategies have been developed including using nanocarriers and chemical modifications.…”

Section: Introductionmentioning

confidence: 99%

Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy

Zhang

Lovell

2016

WIREs Nanomed Nanobiotechnol

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138

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With high extinction coefficients and long absorption wavelengths in the near infrared region, phthalocyanines (Pcs) and naphthalocyanines (Ncs) are well-suited for optical imaging and phototherapies in biological tissues. Pcs and Ncs have been used in a range of theranostic applications. Peripheral and axial substituents can be introduced to Pcs and Ncs for chemical modification. Seamless metal chelation of Pcs or Ncs can expand their possibilities as medical therapeutic and imaging agents. Nanoparticulate approaches enable unique ways to deliver Pcs and Ncs to target tissues and improve their solubility, biocompatibility, biodistribution and stability. Herein, we highlight some recent Pc or Nc nanoscale systems for theranostic applications.

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Therapeutic surfactant-stripped frozen micelles

Cited by 75 publications

References 43 publications

Surfactant‐Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

Surfactant‐Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

Advanced Functional Nanomaterials for Theranostics

Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy

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